PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development
PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development
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PRKX 是一种新型 cAMP 依赖性蛋白激酶成员，在发育中发挥重要作用
DOI：
10.1002/jcb.25304
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发表时间：
2016-03-01
影响因子：
4
通讯作者：
Li, Xiaohong
中科院分区：
文献类型：
--
作者：
Huang, Sizhou;Li, Qian;Li, Xiaohong
人蛋白激酶X基因(PRKX)和cAMP依赖的蛋白激酶(PKA)都是AGC亚类中依赖c-AMP的丝氨酸/苏氨酸蛋白激酶。在这一组的所有蛋白激酶中，PRKX是研究最少的。PRKX已经从点状软骨发育不良患者中分离出来，参与了许多过程，包括性分化和受精、正常肾脏发育和常染色体显性遗传性多囊肾病(ADPKD)、血液成熟、神经发育和体外血管生成。虽然最近报道了PRKX在发育和疾病中的作用，但PRKX活性的潜在机制在很大程度上还不清楚。此外，基于PRKX的表达模式和PKA在疾病和发育中的广泛作用，PRKX可能具有文献中没有讨论的其他关键功能。本文就近年来研究报道的PRKX的特性和发育功能作一综述。特别是，我们阐明了PRKX和PKA在结构和功能上的差异，以及PRKX在发育和相关疾病中的可能作用。最后，我们建议未来的研究可能导致(C)2015威利期刊，公司。
The human protein kinase X gene (PRKX) and cAMP-dependent protein kinase (PKA) are both c-AMP-dependent serine/threonine protein kinases within the protein kinase AGC subgroup. Of all the protein kinases in this group, PRKX is the least studied. PRKX has been isolated from patients with chondrodysplasia punctate and is involved in numerous processes, including sexual differentiation and fertilization, normal kidney development and autosomal dominant polycystic kidney disease (ADPKD), blood maturation, neural development, and angiogenesis in vitro. Although the role of PRKX in development and disease has been reported recently, the underlying mechanism of PRKX activity is largely unknown. In addition, based on the expression pattern of PRKX and the extensive role of PKA in disease and development, PRKX might have additional crucial functions that have not been addressed in the literature. In this review, we summarize the characteristics and developmental functions of PRKX that have been reported by recent studies. In particular, we elucidate the structural and functional differences between PRKX and PKA, as well as the possible roles of PRKX in development and related diseases. Finally, we propose future studies that could lead to (C) 2015 Wiley Periodicals, Inc.