A common haplotype of carnitine palmitoyltransferase 1b is associated with the metabolic syndrome
A common haplotype of carnitine palmitoyltransferase 1b is associated with the metabolic syndrome
复制标题
DOI：
10.1017/s0007114512002656
复制
发表时间：
2013-03-14
影响因子：
3.6
通讯作者：
Schrezenmeir, J.
中科院分区：
文献类型：
--
作者：
Auinger, A.;Rubin, D.;Schrezenmeir, J.
肉碱棕榈酰转移酶 (CPT) 酶系统促进长链脂肪酸转运到线粒体中，为 β-氧化提供底物。我们进行了一项分析，包括 CPT1b 基因肌肉亚型中的三个编码 SNP（rs3213445、rs2269383 和 rs470117）和 CPT2 基因中的一个编码 SNP（rs1799821），以寻找与代谢综合征 (MetS) 特征的关联。对来自基尔代谢干预队列的男性参与者 (n 755) 进行了 MetS 特征的基因分型和表型分析。参与者在标准化混合餐后接受了葡萄糖耐量测试和代谢变量的餐后评估。罕见的 CPT1b 66V (rs3213445) 等位基因的携带者具有显着较高的 γ-谷氨酰转肽酶 (GGT)、谷氨酸草酰乙酸转氨酶 (GOT) 和谷氨酸丙酮酸转氨酶 (GPT) 活性 (P
The carnitine palmitoyltransferase (CPT) enzyme system facilitates the transport of long-chain fatty acids into mitochondria to provide substrates for beta-oxidation. We performed an analysis including three coding SNP in the muscle isoform of the CPT1b gene (rs3213445, rs2269383 and rs470117) and one coding SNP in the CPT2 gene (rs1799821) to find associations with traits of the metabolic syndrome (MetS). Male participants (n 755) from the Metabolic Intervention Cohort Kiel were genotyped and phenotyped for features of the MetS. Participants underwent a glucose tolerance test and a postprandial assessment of metabolic variables after a standardised mixed meal. Carriers of the rare CPT1b 66V (rs3213445) allele had significantly higher gamma-glutamyl transpeptidase (GGT), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvate transaminase (GPT) activities (P