Sensing damage by the NLRP3 inflammasome.
Sensing damage by the NLRP3 inflammasome.
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DOI：
10.1111/j.1600-065x.2011.01043.x
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发表时间：
2011-09
影响因子：
8.7
通讯作者：
Sutterwala FS
中科院分区：
文献类型：
--
作者：
Leemans JC;Cassel SL;Sutterwala FS
The NLRP3 inflammasome is activated in response to a variety of signals that are indicative of damage to the host including tissue damage, metabolic stress, and infection. Upon activation, the NLRP3 inflammasome serves as a platform for activation of the cysteine protease caspase-1, which leads to the processing and secretion of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18. Dysregulated NLRP3 inflammasome activation is associated with both heritable and acquired inflammatory diseases. Here we review new insights into the mechanism of NLRP3 inflammasome activation and its role in disease pathogenesis.
