Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts
Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts
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DOI：
10.1016/j.envres.2023.117230
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发表时间：
2023-10-12
影响因子：
8.3
通讯作者：
Raaschou-Nielsen，Ole
中科院分区：
文献类型：
--
作者：
Hvidtfeldt，Ulla Arthur;Chen，Jie;Raaschou-Nielsen，Ole
背景空气污染是全球日益关注的问题，对人类健康有重大影响。多发性骨髓瘤是一种发病率不断上升的血癌。研究表明空气污染暴露与各种类型的癌症有关，包括白血病和淋巴瘤，然而，与多发性骨髓瘤发病率的关系尚未得到广泛研究。（N = 234，803），并评估了住宅暴露于二氧化氮（NO2）、细颗粒物（PM2.5），黑碳（BC）和臭氧（O3）和多发性骨髓瘤。我们应用考克斯比例风险模型调整潜在的混杂因素在个人和area-level.ResultsDuring 4，415，817人年的后续行动（平均18.8年），我们观察到404例多发性骨髓瘤。完全校正线性分析的结果显示，（95%置信区间）为0.99（0.84，1.16）每10 μg/m³ NO2，1.04（0.82，1.33）每5微克/立方米PM2.5，0.99（0.84，1.18）每0.5 10− 5 m − 1 BCE，和1.11（0.87，1.41）/10 μg/m³ O3。结论长期大气污染暴露与多发性骨髓瘤发病率无相关性。
BackgroundAir pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated.MethodsWe pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone (O3) and multiple myeloma. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.ResultsDuring 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO2, 1.04 (0.82, 1.33) per 5 μg/m³ PM2.5, 0.99 (0.84, 1.18) per 0.5 10−5m−1BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O3.ConclusionsWe did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.