Development and function of tissue resident macrophages in mice.
Development and function of tissue resident macrophages in mice.
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DOI：
10.1016/j.smim.2016.03.017
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发表时间：
2015-12
影响因子：
7.8
通讯作者：
Gomez Perdiguero E
中科院分区：
文献类型：
--
作者：
Kierdorf K;Prinz M;Geissmann F;Gomez Perdiguero E
巨噬细胞对于组织发育、体内平衡以及损伤或感染后的免疫应答是重要的。很长一段时间以来，它们只是被视为一个统一的吞噬细胞群，具有共同的起源和相似的功能。然而，这一观点在过去十年中受到了挑战，并揭示了组织驻留巨噬细胞的复杂多样性。在这里，我们想提出目前的观点，巨噬细胞的发展和组织规格，我们将讨论的差异以及异质性巨噬细胞亚群之间的共同模式。
Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversity of tissue resident macrophages. Here, we want to present the current view on macrophage development and tissue specification and we will discuss differences as well as common patterns between heterogeneous macrophage subpopulations.