Intracranial Segmental Arterial Mediolysis Report of 2 Cases and Review of the Literature
Intracranial Segmental Arterial Mediolysis Report of 2 Cases and Review of the Literature
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DOI：
10.1097/paf.0b013e31828879e8
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发表时间：
2013-06-01
影响因子：
1
通讯作者：
Ang, Lee-Cyn
中科院分区：
文献类型：
--
作者：
Alturkustani, Murad;Ang, Lee-Cyn
广泛的非创伤性蛛网膜下腔出血是导致年轻人意外死亡的重要原因。节段性动脉中溶(SAM)是与这类出血相关的颅内血管的一种罕见的病理发现。节段性动脉中膜溶解是一种可能的血管痉挛病因的病理实体，最近被报道与Ehler-Danlos综合征4型有关。我们描述另外2例具有SAM特征的颅内椎动脉破裂导致致命性蛛网膜下腔出血。我们还回顾了具有SAM特征的血管的文献，这些血管要么是颅内的，要么是影响颈内动脉的，对中枢神经系统有重大的直接影响(即中风或短暂性脑缺血发作)。
Extensive nontraumatic subarachnoid hemorrhage is an important cause of unexpected death in young adults. Segmental arterial mediolysis (SAM) represents an uncommon pathologic finding in the intracranial blood vessels associated with this type of hemorrhage. Segmental arterial mediolysis is a pathologic entity with putative vasospastic etiology, which recently has been reported to be associated with Ehlers-Danlos syndrome type 4. We describe 2 additional cases of ruptured intracranial vertebral artery with features of SAM that resulted in fatal subarachnoid hemorrhage. We also review the literature on vessels with features of SAM that are either intracranial or affecting the internal carotid artery with major direct effects (ie, stroke or transient ischemic attack) on the central nervous system.