[A case-control study on correlation of pesticide exposure with childhood acute leukemia].
[A case-control study on correlation of pesticide exposure with childhood acute leukemia].
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DOI：
10.3760/cma.j.issn.0253-9624.2011.01.011
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发表时间：
2011
影响因子：
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通讯作者：
Yan Zhang;Shanmei Zhu;Yu Gao;Xiao-jin Wang;Tao Chen;You Yang;Guo-quan Wang;Guo-hua Hu;R. Shi;P. Jin;Ying Tian
中科院分区：
文献类型：
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作者：
Yan Zhang;Shanmei Zhu;Yu Gao;Xiao-jin Wang;Tao Chen;You Yang;Guo-quan Wang;Guo-hua Hu;R. Shi;P. Jin;Ying Tian
目的探讨农药暴露与儿童急性白血病的关系。方法对上海市15岁以下儿童急性白血病患者进行探索性病例对照研究。病例组为2006年1月1日至2008年12月31日上海儿童医学中心收治的80例初治急性白血病患者。对照组为96例年龄匹配的健康体检、儿科治疗或骨科治疗的患者，不包括血液系统疾病和肿瘤疾病。对两组进行问卷调查，并从每个参与者中收集30 - 40 ml随机尿液样本。采用气相色谱-火焰分光光度法对样品中的5种有机磷农药代谢物进行了检测。结果问卷调查结果显示，病例组有55.0%（44/80）的儿童使用灭蚊剂，高于对照组的33.3%（32/96），灭蚊剂可能增加儿童急性白血病的发病风险（OR = 2.444，95%CI：1.326 ~ 4.506）。同时检测显示，病例组有机磷代谢产物磷酸二乙酯、磷酸二甲酯、硫代磷酸二甲酯、硫代磷酸二乙酯、二硫代磷酸二乙酯的浓度（中位数）分别为0.0682、0.0082、0.0183、0.0233、0.4259 µg/g Cr，均显著高于对照组（0.0865，0.0025，0.0112，0.0123，0.1207 µg/g Cr），磷酸二乙酯浓度除外（Z =-1.081，P = 0.279）。差异有统计学意义（Z =-5.752，-2.800，-3.316，-8.120，P < 0.05）。结论农药接触可能是儿童急性白血病的危险因素之一。
OBJECTIVE To evaluate the correlation of pesticide exposure with childhood acute leukemia. METHODS An exploratory case-control study was conducted among childhood acute leukemia patients under 15 years old in Shanghai, China. From January 1st, 2006 to December 31st, 2008, a total of 80 newly diagnosed acute leukemia patients were recruited from Shanghai Children's Medical Center for the case group. Another 96 age-matched patients who visited the hospital for health examination, pediatric treatment or osteological therapy excluding hematological system diseases and neoplastic disease, were recruited for the control group. A questionnaire survey was conducted in both groups; and a 30 - 40 ml random urine sample was collected from each participant. Five types of organophosphorus pesticide metabolites was then detected among the samples, using Gas Chromatography with Flame Spectrophotometry. RESULTS According to result of the questionnaire survey, more participants (55.0% (44/80)) in case group than in the control group (33.3% (32/96)) reported using mosquitocidal, which might increase the risk of childhood acute leukemia (OR = 2.444; 95%CI: 1.326 - 4.506). At the same time, the detection showed that the concentration (median) of organophosphate metabolites diethyl phosphate, dimethyl phosphate, dimethyl thiophosphate, diethyl thiophosphate and diethyl dithiophosphate in case group were 0.0682, 0.0082, 0.0183, 0.0233, 0.4259 µg/g Cr, which were all significantly higher than in control group (0.0865, 0.0025, 0.0112, 0.0123, 0.1207 µg/g Cr) except the concentration of diethyl phosphate (Z = -1.081, P = 0.279). The difference showed statistical significance (Z = -5.752, -2.800, -3.316, -8.120, P < 0.05). CONCLUSION Pesticide exposure may be one of the risk factors for childhood acute leukemia.