THE EFFECT OF RIBOFLAVIN DEFICIENCY IN RATS ON THE ABSORPTION AND DISTRIBUTION OF IRON
THE EFFECT OF RIBOFLAVIN DEFICIENCY IN RATS ON THE ABSORPTION AND DISTRIBUTION OF IRON
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DOI：
10.1079/bjn19880047
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发表时间：
1988-05-01
影响因子：
3.6
通讯作者：
FAIRWEATHERTAIT, SJ
中科院分区：
文献类型：
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作者：
POWERS, HJ;WRIGHT, AJA;FAIRWEATHERTAIT, SJ
1.核黄素可能在铁通过胃肠道粘膜的转运中起作用。通过使用小动物γ-Fe监测59 Fe剂量的全身保留来测量大鼠中的Fe吸收。柜台2.从5周龄开始，雌性挪威连帽大鼠喂食缺乏核黄素（B2-）的饮食。对照组动物（饲喂完全（B2+））与饲喂B2-饲料的大鼠体重匹配。7周后，所有大鼠喂以59 Fe标记的试验餐，并测量全身放射性，持续15天。3.核黄素缺乏与吸收剂量百分比的减少和吸收后铁损失率的增加有关。4.核黄素缺乏动物的肝脏中存在较小百分比的吸收剂量。
1. Riboflavin may play a part in the transport of iron across the gastrointestinal mucosa. Fe absorption was measured in the rat by monitoring whole-body retention of a dose of 59Fe using a small-animal .gamma.-counter. 2. Female Norwegian Hooded rats were fed on a diet deficient in riboflavin (B2-) from 5 weeks of age. Control animals, fed on a complete (B2+), were weight-matched to rats fed on the B2- diet. After 7 weeks all rats were fed on a test meal extrinsically labelled with 59Fe and whole-body radioactivity measured for 15 d. 3. Riboflavin deficiency was associated with a reduction in the percentage of the dose absorbed and an increase in the rate of loss of Fe post absorption. 4. A smaller percentage of the absorbed dose was present in the livers of the riboflavin-deficient animals.