Alternations in behaviour in adults offspring mice following maternal inflammation during pregnancy
Alternations in behaviour in adults offspring mice following maternal inflammation during pregnancy
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DOI：
10.1002/dev.20116
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发表时间：
2006-03-01
影响因子：
2.2
通讯作者：
Mahoud, H
中科院分区：
文献类型：
--
作者：
Hava, G;Vered, L;Mahoud, H
怀孕期间母亲的宫内炎症对后代的神经发育脑损伤构成主要威胁，并可能导致认知和知觉结果不佳。在小鼠中，我们之前已经证明，妊娠第 17 天时脂多糖 (LPS) 诱导的母体炎症会增加胎儿大脑中促炎细胞因子 IL-6 的水平。在这项研究中，我们使用相同的系统并检查了短暂的、全身性的母体炎症对后代焦虑和社会行为的影响。正如高架十字迷宫所示，母体炎症组的成年后代表现出焦虑增加。当来自不同窝的两只不熟悉的小鼠被引入新的笼子时，测试组的后代之间的社交互动被检查。母体炎症组的后代表现出活动减少，表明恐惧增加。此外，与对照组的后代相比，母体炎症组的后代对笼中同伴的攻击性较小，在互动的前 30 分钟内，它们花费明显更长的时间修剪笼中同伴的胡须。我们的数据表明，短暂的全身性母体炎症对成年小鼠的压力和社会行为具有长期的影响 (c) 2006 Wiley, periodicals, Inc.
Maternal intrauterine inflammation during pregnancy poses a major threat of neurodevelopmental brain damage in offspring and may cause poor cognitive and perceptual outcomes. In mice, we have previously shown that maternal inflammation induced by lipopolysaccharide (LPS) at gestation day 17th increased the levels of the pro-inflammatory cytokine IL-6 in the fetal brain. In this 1 study, we used the same system and examined the effect of short, systemic maternal inflammation on anxiety and social behavior of the offspring. Adult offspring from the maternal inflammation group showed increased anxiety, as indicated by the elevated plus maze. Social interaction among offspring from the test groups was examined when two unfamiliar mice from different litters were introduced into a new home-cage. Offspring from the maternal inflammation group showed reduced activity, indicating increased fear In addition, offspring from the maternal inflammation group were less aggressive towards their cagemates and they spent a significantly longer time trimming the whiskers of their cagemates during the first 30 min of their interaction, compared to offspring from the control group. Our data suggest that short systemic maternal inflammation have long-lasting consequences on the adult mouse stress and social behavior (c) 2006 Wiley, Periodicals, Inc.