Evaluation of Carnitine Levels According to the Peritoneal Equilibration Test in Patients on Continuous Ambulatory Peritoneal Dialysis
Evaluation of Carnitine Levels According to the Peritoneal Equilibration Test in Patients on Continuous Ambulatory Peritoneal Dialysis
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根据腹膜平衡试验评价连续不卧床腹膜透析患者的肉毒碱水平
DOI：
10.1177/089686089301302s112
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发表时间：
1993
影响因子：
2.8
通讯作者：
K. Kalaitzidis
中科院分区：
文献类型：
--
作者：
Christos Chatzidimitriou;T. Pliakogiannis;A. Evangeliou;Theodora Tsalkidou;H. Böhles;K. Kalaitzidis
连续不卧床腹膜透析（CAPO）患者肉毒碱代谢异常的证据尚不清楚，之前的研究报告了相互矛盾的结果。根据腹膜平衡测试（快速 PE 测试）的结果，对接受 CAPO 的 29 名患者的血液和透析液中的总肉碱 (TC)、游离肉碱 (FC) 和酰化肉碱 (AC) 以及 AC/FC 比率进行了评估，将其分为高吸收体 (H-Abs) 和低吸收体 (L-Abs)。我们的数据表明，腹膜转运率较高的患者，即 H-Abs 组，无论男性还是女性，与 L-Abs 组相比，表现出更好的肉碱代谢状态。尽管H-Abs组比L-Abs组丢失了更多的游离肉碱，但H-Abs组的AC/FC比值仍保持在正常范围内。我们研究中的所有患者均表现出异常高的甘油三酯 (TAG) 水平和异常高的总胆固醇/HOL 胆固醇比率。特别是，L-Abs 组患者的 TAG 水平和总胆固醇/HOL 胆固醇比值显着高于 H-Abs 组。那些接受 CAPO 治疗超过 2 年的患者比那些接受 CAPO 治疗时间较短的患者表现出显着异常较高的 AC/FC 比值。对于AC/FC比值大于0.4的患者，补充左旋肉碱可能对其肉碱和脂质代谢产生有益影响。
The evidence of carnitine abnormal metabolism in patients on continuous ambulatory peritoneal dialysis (CAPO) is unclear, and previous studies have reported conflicting results. The total (TC), free (FC), and acylated (AC) carnitines were estimated in blood and dialysate, as well as the AC/FC ratio, in 29 patients on CAPO, grouped into high (H-Abs) and low (L-Abs) absorbers, according to the results of the peritoneal equilibration test (fast PE-test). Ourdata demonstrated that patients with higher peritoneal transport rates, which was the H-Abs group, males and females, showed a better carnitine metabolic status compared to the L-Abs group. Although the H-Abs group lost significantly more free carnitine than the L-Abs group, the AC/FC ratio of the H-Abs group remained within normal range. All the patients in our study showed abnormally high triglyceride (TAG) levels and an abnormally high total cholesterol/HOL cholesterol ratio. In particular, the patients In the L-Abs group showed significantly higher TAG levels and total cholesterol/HOL cholesterol ratios than the H-Abs group. Those patients who have been on CAPO for more than 2 years showed significantly abnormally higher AC/FC ratios than those with shorter periods on CAPO treatment. In patients with AC/FC ratio greater than 0.4, the supplementation of L-carnitine may have a beneficial effect on their carnitine and lipid metabolism.