Degree of supersaturation-regulated chiral symmetry breaking in one crystal.
Degree of supersaturation-regulated chiral symmetry breaking in one crystal.
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一个晶体中过饱和调节的手性对称性破缺程度。
DOI：
10.1021/jp075238p
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Yi Chen
中科院分区：
文献类型：
--
作者：
Meirong Liu;Changgui Qiu;Zhenpeng Guo;L. Qi;Mingyi Xie;Yi Chen
本文旨在研究单晶体中的手征性破缺现象。在无晶种的停滞溶液中，通过缓慢冷却进行了外消旋天冬酰胺的优先结晶。通过改变过饱和度，当dl-天冬酰胺的过饱和度足够低时，只能得到一个透明晶体，且该晶体不是纯的对映体，晶体对映体过量与过饱和度成反比。在一个透明晶体中，晶体对映体过量可高达85%。由于没有二次成核发生，除了随机初级成核，我们认为初级成核和l-和d-核之间的竞争被认为是不对称放大的机制。采用高效毛细管电泳-激光诱导荧光法对左旋和右旋天冬酰胺进行分离和定量，并根据其浓度计算对映体过量值。
This paper aimed at studying chiral symmetry-breaking phenomena in one crystal. Preferential crystallization of racemic asparagines was carried out in nonseeded stagnant solutions through slow cooling. By varying the supersaturation, only one transparent crystal could be obtained at enough low supersaturation of dl-asparagine, and the crystal was not pure enantiomer with crystal enantiomeric excess increasing inversely with the degree of supersaturation. Crystal enantiomeric excess can amount up to 85% in one transparent crystal. Because no secondary nucleation occurred except for stochastic primary nucleation, we suggest that primary nucleation and competition between l- and d-nuclei were considered to be a mechanism for asymmetry amplification. High-performance capillary electrophoresis coupled with laser-induced fluorescence was used to separate and quantify l- and d-asparagine and the enantiomeric excess value can be calculated according to their concentration.