A new potent antifungal agent from Actinoplanes sp.
A new potent antifungal agent from Actinoplanes sp.
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DOI：
10.1016/s0040-4039(98)01696-7
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发表时间：
1998-10-15
影响因子：
1.8
通讯作者：
Chan, TM
中科院分区：
文献类型：
--
作者：
Chu, M;Truumees, I;Chan, TM
从一株游动放线菌的发酵液中分离得到一种新的抗真菌剂Sch 56036（1），通过光谱分析确定了其结构。化合物1经鉴定为一个新的多环口山酮。1的生物学评价表明，该化合物对各种酵母菌和皮肤真菌具有广谱抗真菌活性，几何平均MIC值分别为0.017 - 0.031 μ g/mL。(C)1998爱思唯尔科技有限公司版权所有。
A novel antifungal agent, Sch 56036 (1), was isolated from the fermentation culture broth of an Actinoplanes sp. Structure elucidation of 1 was accomplished by the analysis of spectroscopic data. Compound 1 was identified as a new polycyclic xanthone. Biological evaluation of 1 indicated that the compound possesses broad spectrum antifungal activity against various yeasts and dermatophytes with geometric mean MIC values ranging from 0.017 similar to 0.031 mu g/mL, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.