Obesity Hypoventilation Syndrome.
Obesity Hypoventilation Syndrome.
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DOI：
10.1007/s13665-015-0108-6
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发表时间：
2015-03-01
影响因子：
0.6
通讯作者：
Parthasarathy S
中科院分区：
文献类型：
--
作者：
Shetty S;Parthasarathy S
肥胖低通气综合征是病态肥胖的呼吸系统后果，其特征是睡眠和清醒时肺泡通气不足。该疾病涉及呼吸力学受损、通气驱动和睡眠呼吸障碍之间复杂的相互作用。早期诊断和治疗很重要，因为延迟治疗与显着的死亡率和发病率相关。可用的治疗方案包括无创气道正压通气 (PAP) 治疗和减肥。关于此类疗法有效性的长期数据有限。这篇综述概述了当前临床表现、诊断和管理策略的概念，以帮助识别和治疗肥胖通气不足综合征患者。
Obesity hypoventilation syndrome is a respiratory consequence of morbid obesity that is characterized by alveolar hypoventilation during sleep and wakefulness. The disorder involves a complex interaction between impaired respiratory mechanics, ventilatory drive and sleep-disordered breathing. Early diagnosis and treatment is important, because delay in treatment is associated with significant mortality and morbidity. Available treatment options include non-invasive positive airway pressure (PAP) therapies and weight loss. There is limited long-term data regarding the effectiveness of such therapies. This review outlines the current concepts of clinical presentation, diagnostic and management strategies to help identify and treat patients with obesity-hypoventilation syndromes.