New Learning and Unlearning: Strangers or Accomplices in Threat Memory Attenuation?
New Learning and Unlearning: Strangers or Accomplices in Threat Memory Attenuation?
复制标题
DOI：
10.1016/j.tins.2016.03.003
复制
发表时间：
2016-05
影响因子：
15.9
通讯作者：
Schiller D
中科院分区：
文献类型：
--
作者：
Clem RL;Schiller D
为了达到最大的疗效，减轻恐惧和焦虑的疗法应该排除情绪反应的重新出现。与这一目标相关的是，威胁记忆减少的临床前模型被认为涉及两个离散的神经过程之一：要么建立一个新的行为反应，与完整的威胁记忆竞争，从而暂时干扰其表达（新学习），要么修改，从而破坏完整的威胁记忆（遗忘）。我们认为，严格的新学习和遗忘的二分法并不能为当前的数据提供令人信服的解释。相反，我们建议的证据值得考虑的替代模型，假设合作，而不是竞争之间形成新的细胞痕迹和修改先前存在的。
To achieve greatest efficacy, therapies for attenuating fear and anxiety should preclude the re-emergence of emotional responses. Of relevance to this aim, preclinical models of threat memory reduction are considered to engage one of two discrete neural processes: either establishment of a new behavioral response that competes with, and thereby temporarily interferes with expression of, an intact threat memory (new learning), or one which modifies and thereby disrupts an intact threat memory (unlearning). We contend that a strict dichotomy of new learning and unlearning does not provide a compelling explanation for current data. Instead, we suggest the evidence warrants consideration of alternative models that assume cooperation rather than competition between formation of new cellular traces and the modification of preexisting ones.