Copper-Catalyzed Radical 1,2-Carbotrifluoromethylselenolation of Alkenes under Ambient Conditions.
Copper-Catalyzed Radical 1,2-Carbotrifluoromethylselenolation of Alkenes under Ambient Conditions.
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DOI：
10.1021/acs.orglett.1c00436
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发表时间：
2021-02
期刊：
影响因子：
5.2
通讯作者：
J. Yu;Ning-Yuan Yang;Jiang Cheng;Tian‐Ya Zhan;Cheng Luan;L. Ye;Qiangshuai Gu;Zhong-Liang Li;Guo-qiang Chen;Xin‐Yuan Liu
中科院分区：
文献类型：
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作者：
J. Yu;Ning-Yuan Yang;Jiang Cheng;Tian‐Ya Zhan;Cheng Luan;L. Ye;Qiangshuai Gu;Zhong-Liang Li;Guo-qiang Chen;Xin‐Yuan Liu
我们已经描述了一种铜催化的自由基1，2-三氟甲基硒化的烯烃使用容易获得的烷基卤化物和（Me 4 N）SeCF 3盐。成功的关键是使用基于脯氨酸的N，N，P-配体来增强铜的还原能力，以通过单电子转移过程将不同的烷基卤化物容易地转化为相应的自由基。该反应的特点是底物范围广，包括具有许多官能团的各种单、二和三取代烯烃。
We have described a copper-catalyzed radical 1,2-carbotrifluoromethylselenolation of alkenes using the readily available alkyl halides and (Me4N)SeCF3 salt. Critical to the success is the use of a proline-based N,N,P-ligand to enhance the reducing capability of copper for easy conversion of diverse alkyl halides to the corresponding radicals via a single-electron transfer process. The reaction features a broad substrate scope, including various mono-, di-, and trisubstituted alkenes with many functional groups.