Hydrogen peroxide vapour decontamination of surfaces artificially contaminated with norovirus surrogate feline calicivirus
Hydrogen peroxide vapour decontamination of surfaces artificially contaminated with norovirus surrogate feline calicivirus
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DOI：
10.1016/j.jhin.2011.10.010
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发表时间：
2012-02-01
影响因子：
6.9
通讯作者：
Bennett, A. M.
中科院分区：
文献类型：
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作者：
Bentley, K.;Dove, B. K.;Bennett, A. M.
背景：诺如病毒是胃肠道疾病的主要原因，在医院等卫生保健机构中引起特别关注。由于据报告该病毒对环境稳定，因此需要在疫情爆发后进行有效的去污处理，以防止再次爆发。目的：研究利用过氧化氢蒸汽净化被诺如病毒替代品猫杯状病毒（FCV）人工污染的一些表面。测试的表面是医院病房中发现的具有代表性的表面。方法：FCV用于污染具有代表性的医院材料（不锈钢、玻璃、乙烯基地板、瓷砖和PVC塑料角）。将携带者暴露在30% （w/w）的过氧化氢蒸气中，间隔5分钟，持续20分钟，之后测量暴露后的病毒滴度。结果：在暴露20分钟内，过氧化氢蒸气在所有测试表面上降低了4 log（10）的病毒滴度。不锈钢地板上的病毒滴度降低时间最长（20分钟），乙烯基地板上的效果最快（10分钟）。对于玻璃、塑料和瓷砖表面，在暴露15分钟内就可以看到病毒滴度的预期降低。过氧化氢蒸汽允许在感染性生物爆发后对区域进行大规模净化。结论：过氧化氢蒸汽对FCV有效，并在一系列表面上有活性。因此，它可能是一个合适的净化系统，用于医院爆发诺如病毒。(C) 2011卫生保健感染学会。Elsevier Ltd.出版。版权所有。
Background: Noroviruses are a leading cause of gastrointestinal disease and are of particular concern in healthcare settings such as hospitals. As the virus is reported to be environmentally stable, effective decontamination following an outbreak is required to prevent recurrent outbreaks.Aim: To investigate the use of hydrogen peroxide vapour to decontaminate a number of surfaces that had been artificially contaminated with feline calicivirus (FCV), a surrogate for norovirus. The surfaces tested were representative of those found in hospital wards.Methods: FCV was used to contaminate materials representative of a hospital setting (stainless steel, glass, vinyl flooring, ceramic tile and PVC plastic cornering). The carriers were exposed to 30% (w/w) hydrogen peroxide vapour at 5-min intervals over 20 min, after which postexposure viral titres were measured.Findings: Hydrogen peroxide vapour reduced the viral titre by 4 log(10) on all surfaces tested within 20 min of exposure. The reduction in viral titre took longest to achieve on stainless steel (20 min), and the quickest effect was seen on vinyl flooring (10 min). For glass, plastic and ceramic tile surfaces, the desired reduction in viral titre was seen within 15 min of exposure. Hydrogen peroxide vapour allows for large-scale decontamination of areas following outbreaks of infectious organisms.Conclusion: Hydrogen peroxide vapour is effective against FCV and is active on a range of surfaces. Therefore, it may represent a suitable decontamination system for use following a hospital outbreak of norovirus. (C) 2011 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.