AIRWAYS INFLAMMATION IN NOCTURNAL ASTHMA
AIRWAYS INFLAMMATION IN NOCTURNAL ASTHMA
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DOI：
10.1164/ajrccm/143.2.351
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发表时间：
1991-02-01
期刊：
影响因子：
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通讯作者：
SZEFLER, SJ
中科院分区：
文献类型：
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作者：
MARTIN, RJ;CICUTTO, LC;SZEFLER, SJ
夜间哮喘是一个常见的问题，但机制尚不清楚。 我们调查了夜间发生气道炎症的可能性。 在16：00和04：00时，分析了伴有（n = 7）和不伴有夜间哮喘（n = 7）的哮喘患者的支气管肺泡灌洗液。 夜间哮喘组总白细胞计数增加（24.0 +/- 7.0至41.1 +/- 9.9 x 10（4）个细胞/ml，p < 0.05），中性粒细胞（1.1 +/- 0.6至3.7 +/- 1.5 × 10（4）个细胞/ml，p < 0.05）和嗜酸性粒细胞（0.5 +/- 0.1至1.7 +/- 0.7 × 10（4）个细胞/ml，p < 0.05）。 非夜间哮喘组的细胞成分没有变化。 各组之间，1600-h细胞相似。 在0400小时，夜间哮喘组的总白细胞、中性粒细胞、嗜酸性粒细胞、淋巴细胞和上皮细胞计数显著升高。 对于所有受试者，夜间呼气峰流速的下降与中性粒细胞（r = 0.54，p < 0.05）和嗜酸性粒细胞（r = 0.77，p < 0.05）的变化相关。 我们的结论是，夜间哮喘恶化有相关的细胞炎症反应，这是没有看到在夜间肺功能下降的患者。 这种炎症反应和上皮损伤可能是夜间哮喘病因学的重要因素。
Nocturnal asthma is a frequent problem, but the mechanism is unclear. We investigated the possibility that airways inflammation occurred during the night. Bronchoalveolar lavage fluid was analyzed in asthmatic patients with (n = 7) and without nocturnal asthma (n = 7) at 1600 and 0400 h. The nocturnal asthma group had an increase in the total leukocyte count (24.0 +/- 7.0 to 41.1 +/- 9.9 x 10(4) cells/ml, p < 0.05), neutrophils (1.1 +/- 0.6 to 3.7 +/- 1.5 x 10(4) cells/ml, p < 0.05), and eosinophils (0.5 +/- 0.1 to 1.7 +/- 0.7 x 10(4) cells/ml, p < 0.05) from 1600 to 0400 h. Cellular components for the non-nocturnal asthma group did not change. Between groups, the 1600-h cells were similar. At 0400 h the nocturnal asthma group had significantly higher total leukocyte, neutrophil, eosinophil, lymphocyte, and epithelial counts. For all subjects, the overnight fall in peak expiratory flow rates was correlated to the change in neutrophils (r = 0.54, p < 0.05) and eosinophils (r = 0.77, p < 0.05). We conclude that the nocturnal worsening of asthma has an associated cellular inflammatory response that is not seen in patients without overnight decrements in lung function. This inflammatory response together with epithelial damage may be important factors in the etiology of nocturnal asthma.