Recent advances in oral insulin delivery technologies.
Recent advances in oral insulin delivery technologies.
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DOI：
10.1016/j.jconrel.2023.12.045
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发表时间：
2023-12
期刊：
影响因子：
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通讯作者：
Ershuai Zhang;Hui Zhu;Boyi Song;Yuanjie Shi;Zhiqiang Cao
中科院分区：
文献类型：
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作者：
Ershuai Zhang;Hui Zhu;Boyi Song;Yuanjie Shi;Zhiqiang Cao
随着世界范围内糖尿病病例的增加，口服递送胰岛素由于其良好的患者依从性和非侵入性、简单性和多功能性而优于皮下胰岛素施用。然而，口服胰岛素递送受到各种胃肠道屏障的阻碍，导致药物生物利用度低和治疗效率不足。已经开发了许多策略来克服这些障碍并提高口服胰岛素的生物利用度。然而，由于与胃肠道的结构组织和生理功能相关的各种实质性障碍，没有商业口服胰岛素产品可用于解决所有临床障碍。在此，我们讨论了阻碍口服胰岛素转运和吸收的重要生理屏障（包括化学、酶和物理屏障）。然后，我们展示了口服胰岛素给药技术的最新重大创新进展。最后，我们总结了口服胰岛素给药技术的未来前景和即将到来的口服胰岛素给药技术的临床翻译的潜在挑战的评论。
With the rise in diabetes mellitus cases worldwide, oral delivery of insulin is preferred over subcutaneous insulin administration due to its good patient compliance and non-invasiveness, simplicity, and versatility. However, oral insulin delivery is hampered by various gastrointestinal barriers that result in low drug bioavailability and insufficient therapeutic efficiency. Numerous strategies have been developed to overcome these barriers and increase the bioavailability of oral insulin. Yet, no commercial oral insulin product is available to address all clinical hurdles because of various substantial obstacles related to the structural organization and physiological function of the gastrointestinal tract. Herein, we discussed the significant physiological barriers (including chemical, enzymatic, and physical barriers) that hinder the transportation and absorption of orally delivered insulin. Then, we showcased recent significant and innovative advances in oral insulin delivery technologies. Finally, we concluded the review with remarks on future perspectives on oral insulin delivery technologies and potential challenges for forthcoming clinical translation of oral insulin delivery technologies.