Weight loss and undernutrition in community-dwelling patients with Alzheimer's dementia From population based studies to clinical management
Weight loss and undernutrition in community-dwelling patients with Alzheimer's dementia From population based studies to clinical management
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DOI：
10.1007/s00391-015-0891-2
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发表时间：
2015-06-01
影响因子：
1.2
通讯作者：
Deyn, P. P.
中科院分区：
文献类型：
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作者：
Droogsma, E.;Asselt, D.;Deyn, P. P.
阿尔茨海默病 (AD) 患者通常会出现体重减轻和营养不良的情况，并与各种不良后果相关。因此，了解对于存在营养状况不良风险的社区 AD 患者的最佳方法是什么非常重要；然而，目前没有证据可以作为营养建议的依据。专家建议营养状况应成为所有 AD 患者检查的一部分。如果 3-6 个月内体重减轻 5% 或更多，或者小型营养评估 (MNA) 将患者归类为营养不良，则应开始营养干预。干预措施应该是多因素的，包括治疗体重减轻和营养不良的潜在原因和危险因素，以及通过增加能量和蛋白质摄入量结合日常体力活动来改善营养状况。
Weight loss and undernutrition are commonly described in patients with Alzheimer's disease (AD) and have been associated with various adverse outcomes. Therefore, it is important to know what the best approach is to community-dwelling AD patients with a risk of developing a poor nutritional status; however, there is currently no evidence on which to base nutritional recommendations. Expert based recommendations are that the nutritional status should be part of the work-up of all AD patients. If weight loss of 5 % or more has occurred in 3-6 months or if the mini-nutritional assessment (MNA) classifies a patient as undernourished, a nutritional intervention should be started. The intervention should be multifactorial and encompass treatment of the underlying proposed causes and risk factors of weight loss and undernutrition as well as improvement of the nutritional status by increasing energy and protein intake combined with daily physical activity.