A Pairwise Meta-Analysis of Induction Chemotherapy in Nasopharyngeal Carcinoma
A Pairwise Meta-Analysis of Induction Chemotherapy in Nasopharyngeal Carcinoma
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鼻咽癌诱导化疗的配对荟萃分析
DOI：
10.1634/theoncologist.2018-0522
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发表时间：
2019-04-01
期刊：
影响因子：
5.8
通讯作者：
Xie, Fang-Yun
中科院分区：
文献类型：
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作者：
OuYang, Pu-Yun;Zhang, Xiao-Min;Xie, Fang-Yun
研究背景局部晚期鼻咽癌有较高的远处转移风险和死亡率。诱导化疗是临床上常用的治疗方法，但其疗效在随机对照试验内外存在较大争议。因此，我们进行了这种成对的meta analysis.Materials and MethodsTrials随机患者接受放疗或同步放化疗或诱导化疗，通过检索PubMed，MEDLINE和。ResultsA共10项试验（2,627例）被纳入。基于固定效应模型的合并风险比（HR）为0.68（95%置信区间[CI] 0.56-0.80，p
BackgroundLocoregionally advanced nasopharyngeal carcinoma has high risk of distant metastasis and mortality. Induction chemotherapy is commonly administrated in clinical practice, but the efficacy was quite controversial in and out of randomized controlled trials. We thus conducted this pairwise meta-analysis.Materials and MethodsTrials that randomized patients to receive radiotherapy or concurrent chemoradiotherapy with or without induction chemotherapy were identified via searches of PubMed, MEDLINE, and .ResultsA total of ten trials (2,627 patients) were included. The pooled hazard ratios (HRs) based on fixed effect model were 0.68 (95% confidence interval [CI] 0.56-0.80, p