Specializations of a pheromonal glomerulus in the Drosophila olfactory system
Specializations of a pheromonal glomerulus in the Drosophila olfactory system
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DOI：
10.1152/jn.00591.2010
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发表时间：
2011-04-01
影响因子：
2.5
通讯作者：
Isacoff, Ehud
中科院分区：
文献类型：
--
作者：
Agarwal, Gautam;Isacoff, Ehud
放大图片作者：J.果蝇嗅觉系统中信息素小球的特化。J Neurophysiol 105：1711 - 1721，2011.首次发表于2011年2月2日; doi：10.1152/jn.00591.2010. -昆虫信息素小球被认为是跟踪一个或几个气味的精细时空特征，以帮助同种定位。然而，目前尚不清楚它们的功能是否与对许多气味有反应的多面手肾小球不同。在这项研究中，我们测试如何DA 1，在果蝇的模型信息素肾小球，代表其输入的空间和时间特性，与其他肾小球相比。我们结合联合收割机钙成像和电刺激在一个孤立的大脑准备的同时，公正的比较功能组织的许多肾小球。与其他肾小球中发现的相反，我们发现同侧和对侧刺激引起DA1内不同的空间活动模式。DA 1的输出显示出更大的偏好，男性比女性同侧刺激。DA1经历更大，更快的抑制比其他肾小球，使其能够报告轻微的触角间延迟刺激发作的“赢家通吃”的方式。DA1的编码时空输入功能的能力区分它从其他肾小球在果蝇触角叶，但它与其他昆虫物种的信息素肾小球。我们建议，DA 1是专门帮助苍蝇本地化和定向信息素来源。
Agarwal G, Isacoff E. Specializations of a pheromonal glomerulus in the Drosophila olfactory system. J Neurophysiol 105: 1711-1721, 2011. First published February 2, 2011; doi:10.1152/jn.00591.2010.-Insect pheromonal glomeruli are thought to track the fine spatiotemporal features of one or a few odorants to aid conspecific localization. However, it is not clear whether they function differently from generalist glomeruli, which respond to many odorants. In this study, we test how DA1, a model pheromonal glomerulus in the fruit fly, represents the spatial and temporal properties of its input, compared with other glomeruli. We combine calcium imaging and electrical stimulation in an isolated brain preparation for a simultaneous, unbiased comparison of the functional organization of many glomeruli. In contrast to what is found in other glomeruli, we find that ipsilateral and contralateral stimuli elicit distinct spatial patterns of activity within DA1. DA1's output shows a greater preference for ipsilateral stimuli in males than in females. DA1 experiences greater and more rapid inhibition than other glomeruli, allowing it to report slight interantennal delays in stimulus onset in a "winner-take-all" manner. DA1's ability to encode spatiotemporal input features distinguishes it from other glomeruli in the fruit fly antennal lobe but relates it to pheromonal glomeruli in other insect species. We propose that DA1 is specialized to help the fly localize and orient with respect to pheromone sources.