Janus kinase 3: the controller and the controlled.
Janus kinase 3: the controller and the controlled.
复制标题
Janus 激酶 3：控制者和被控制者。
DOI：
10.1093/abbs/gmr105
复制
发表时间：
2012
影响因子：
3.7
通讯作者：
Sun,Xiao-Hong
中科院分区：
文献类型：
--
作者：
Wu,Wei;Sun,Xiao-Hong
Janus激酶（JAK）-信号转导和转录激活因子（STAT）信号通路在淋巴细胞生成中起重要作用。具体地，JAK 3在淋巴系统中具有独特的功能，使得JAK 3消融导致类似于严重联合免疫缺陷综合征的表型。本文就JAK 3的生物化学、免疫学功能及其临床意义作一综述。与JAK家族的其他成员相比，JAK 3的生物化学性质相对不太好表征，因此主要从JAK 2的研究中推断。此外，有关Notch和JAK信号通路通过泛素介导的蛋白质降解之间的交叉会谈的新发现进行了更详细的讨论。
Janus kinase (JAK)-signal transducer and activators of transcription (STAT) signaling pathways play crucial roles in lymphopoiesis. In particular, JAK3 has unique functions in the lymphoid system such that JAK3 ablation results in phenotypes resembling severe combined immunodeficiency syndrome. This review focuses on the biochemistry, immunological functions, and clinical significance of JAK3. Compared with other members of the JAK family, the biochemical properties of JAK3 are relatively less well characterized and thus largely inferred from studies of JAK2. Furthermore, new findings concerning the cross-talks between Notch and JAK signaling pathways through ubiquitin-mediated protein degradation are discussed in more detail.