ORIGINS OF SEROTONERGIC PROJECTIONS TO THE SPINAL-CORD IN RAT - AN IMMUNOCYTOCHEMICAL-RETROGRADE TRANSPORT STUDY
ORIGINS OF SEROTONERGIC PROJECTIONS TO THE SPINAL-CORD IN RAT - AN IMMUNOCYTOCHEMICAL-RETROGRADE TRANSPORT STUDY
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DOI：
10.1016/0006-8993(81)91092-1
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发表时间：
1981-01-01
期刊：
影响因子：
2.9
通讯作者：
COULTER, JD
中科院分区：
文献类型：
--
作者：
BOWKER, RM;WESTLUND, KN;COULTER, JD
Origins of the serotonergic projections to the spinal cord in the rat were determined by employing the retrograde cell marker HRP [horseradish peroxidase] coupled with the unlabeled antibody, peroxidase-antiperoxidase immunocytochemical method of Sternberger. Large numbers of stained neurons (> 70%) in the medullary raphe nuclear complex contained both HRP retrogradely transported from the spinal cord and positive 5-HT [serotonin] staining. These serotonergic cell groups, including the nucleus raphe obscurus, raphe pallidus, raphe magnus and ventral parts of the reticular formation, project to all spinal cord levels. Some neurons contained HRP granules, but were unstained for 5-HT, suggesting that they may contain other non-serotonergic neurotransmitters. More rostrally in the midbrain reticular formation, many 5-HT neurons had projections exclusively to the cervical spinal cord. The descending serotonin inputs to the spinal cord apparently originate not only from the serotonergic neurons located in the medullary raphe complex, but also from other new sources located in the central gray and reticular formation of the midbrain.
