Evidence for central command activation of the human insular cortex during exercise.
Evidence for central command activation of the human insular cortex during exercise.
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运动期间人类岛叶皮层中央命令激活的证据。
DOI：
10.1152/japplphysiol.01152.2002
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Mathews,D
中科院分区：
文献类型：
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作者：
Williamson,JW;McColl,R;Mathews,D
本研究的目的是确定是否中央命令激活岛叶皮层区域，独立于肌肉代谢反射激活和血压升高。受试者（n= 8）在1）休息时袖带闭塞，2）静态握力运动（SHG）足以使平均血压（MBP）升高15 mmHg，3）SHG运动后袖带闭塞（PECO）以维持15 mmHg的血压升高。通过单光子发射计算机断层扫描收集心率、MBP、感觉劳累和不适评分以及局部脑血流量（rCBF）数据。当比较SHG和PECO期间MBP匹配的时间段时，SHG的心率（7 ± 3次/min;P< 0.05）和自感劳累评分（15 ± 2个单位;P< 0.05）更高。SHG期间，手部感觉运动区（9 ± 3%）、右下后扣带回（7 ± 3%）、左下前扣带回（8 ± 2%）和前扣带回（6 ± 2%）的rCBF显著增加，而PECO期间未发现。SHG和PECO的下（腹侧）丘脑和右下前岛叶均明显激活。虽然先前的研究表明，岛叶皮层的区域可以独立于机械反射输入激活，但目前还没有评估。这些研究结果提供的证据表明，有岛叶和前扣带皮层的区域内的rCBF的变化与中央命令本身在握力运动，独立的代谢反射激活和血压升高。
The purpose of this investigation was to determine whether central command activated regions of the insular cortex, independent of muscle metaboreflex activation and blood pressure elevations. Subjects (n= 8) were studied during1) rest with cuff occlusion,2) static handgrip exercise (SHG) sufficient to increase mean blood pressure (MBP) by 15 mmHg, and3) post-SHG exercise cuff occlusion (PECO) to sustain the 15-mmHg blood pressure increase. Data were collected for heart rate, MBP, ratings of perceived exertion and discomfort, and regional cerebral blood flow (rCBF) by using single-photon-emission computed tomography. When time periods were compared when MBP was matched during SHG and PECO, heart rate (7 ± 3 beats/min;P< 0.05) and ratings of perceived exertion (15 ± 2 units;P< 0.05) were higher for SHG. During SHG, there were significant increases in rCBF for hand sensorimotor (9 ± 3%), right inferior posterior insula (7 ± 3%), left inferior anterior insula (8 ± 2%), and anterior cingluate regions (6 ± 2%), not found during PECO. There was significant activation of the inferior (ventral) thalamus and right inferior anterior insular for both SHG and PECO. Although prior studies have shown that regions of the insular cortex can be activated independent of mechanoreflex input, it was not presently assessed. These findings provide evidence that there are rCBF changes within regions of the insular and anterior cingulate cortexes related to central command per se during handgrip exercise, independent of metaboreflex activation and blood pressure elevation.