New Efficient Synthesis of 1,2,4-Trisubstituted Furans by a Sequential Passerini/Wittig/Isomerization Reaction Starting from Baylis-Hillman beta-Bromo Aldehydes
New Efficient Synthesis of 1,2,4-Trisubstituted Furans by a Sequential Passerini/Wittig/Isomerization Reaction Starting from Baylis-Hillman beta-Bromo Aldehydes
复制标题
以 Baylis-Hillman β-溴醛为原料，通过连续 Passerini/Wittig/异构化反应高效合成 1,2,4-三取代呋喃
DOI：
10.1055/s-0036-1588564
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发表时间：
2018
期刊：
影响因子：
2
通讯作者：
Ding Ming Wu
中科院分区：
文献类型：
--
作者：
Ren Zhi Lin;Sun Mei;Guan Zhi Rong;Ding Ming Wu
以Baylis-Hillman β-溴代醛、酸、异腈和甲基（二苯基）膦为原料，在三乙胺存在下，经Passerini缩合、Wittig反应和异构化反应合成了1，2，4-三取代呋喃。
A new and efficient synthesis of 1,2,4-trisubstituted furans from a Baylis–Hillman β-bromo aldehyde, an acid, an isocyanide, and methyl(diphenyl)phosphine, by a sequential Passerini condensation, Wittig reaction, and isomerization in the presence of triethylamine is reported.