Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion
Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion
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DOI：
10.1080/14017430601071849
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发表时间：
2007-01-01
影响因子：
2.2
通讯作者：
Arheden, Hakan
中科院分区：
文献类型：
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作者：
Hedstrom, Erik;Astrom-Olsson, Karin;Arheden, Hakan
目标.探讨急性再灌注后肌酸激酶MBmass（CKMB）和心肌肌钙蛋白T（cTnT）的达峰时间，比较峰值和累积值以估计梗死面积（IS），并评价临床常规采样评估IS的价值。设计对38例首次心肌梗死患者进行急性直接经皮冠状动脉介入治疗（PCI）。在21例患者中，在PCI前和PCI后1.5、3、6、12、18、24和48小时采集CKMB和cTnT。在17例患者中，在到达时以及10和20 h采集临床常规样本。通过延迟对比增强MRI（DE-MRI）评估IS。结果CKMB的达峰时间为7.6 +/- 3.6 h，cTnT为8.1 +/- 3.4 h。峰值与累积值（r（s）= 0.97-0.98）以及DE-MRI（r（s）= 0.8 - 0.82）密切相关。临床常规采样显示较低的r（s）值（0.47 - 0.60）。结论.如果在急性PCI后3、6和12 h采集CKMB和cTnT，则可能捕获峰值。这些峰值可以用来估计急性PCI后心肌梗死范围。
Objectives. To find the time-to-peak for creatine kinase MBmass (CKMB) and cardiac troponin T (cTnT) after acute reperfusion, to compare peak and cumulative values to estimate infarct size (IS), and to evaluate clinical routine sampling for assessment of IS. Design. Acute primary percutaneous coronary intervention (PCI) was performed in 38 patients with first-time myocardial infarction. In 21 patients, CKMB and cTnT were acquired before PCI and at 1.5, 3, 6, 12, 18, 24, and 48 hours thereafter. In 17 patients, clinical routine samples were acquired at arrival, and at 10 and 20 h. IS was assessed by delayed contrast-enhanced MRI (DE- MRI). Results. Time-to-peak was 7.6 +/- 3.6 h for CKMB and 8.1 +/- 3.4 h for cTnT. Peak values correlated strongly to cumulative values (r(s) = 0.97-0.98) as well as to DE-MRI (r(s) = 0.8 - 0.82). Clinical routine sampling showed lower r(s) values (0.47 - 0.60). Conclusions. Peak values are likely captured if CKMB and cTnT are acquired at 3, 6, and 12 h after acute PCI. These peak values can be used to estimate myocardial infarct size after acute PCI.