Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge.
Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge.
复制标题
内侧前额叶皮质中的 P2X2 受体参与 ATP 调节对行为挑战的被动应对反应。
DOI：
10.1111/gbb.12691
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Gao Tian-Ming
中科院分区：
文献类型：
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作者：
Kong Ying;Wang Qian;Wu Ding-Yu;Hu Jian;Zang Wen-Si;Li Xiao-Wen;Yang Jian-Ming;Gao Tian-Ming
P2 X2和P2 X3受体广泛表达于外周神经系统和中枢神经系统，已被证实参与不同的外周感觉功能，但关于P2 X2和P2 X3受体参与动物行为的研究很少。在这里，我们使用P2 X2和P2 X3敲除小鼠来解决这个问题。P2 X2基因敲除小鼠表现出正常的运动功能、探索行为、焦虑样行为、学习和记忆行为以及对行为挑战的被动应对反应。然而，在内侧前额叶皮层（mPFC）的ATP输注的效果上的被动应对反应被阻断P2 X2，而不是P2 X3受体删除。此外，在P2 X3敲除小鼠中未观察到各种行为测试的缺陷。这些发现证明了mPFC中的P2 X2受体在腺苷-5 ′-三磷酸调节对行为挑战的被动应对反应中的作用，并表明P2 X2/P2 X3受体与行为有关。
P2X2 and P2X3 receptors are widely expressed in both the peripheral nervous system and the central nervous system and have been proven to participate in different peripheral sensory functions, but there are few studies on the involvement of P2X2 and P2X3 receptors in animal behaviors. Here we used P2X2 and P2X3 knockout mice to address this issue. P2X2 knockout mice showed normal motor function, exploratory behavior, anxiety‐like behaviors, learning and memory behaviors and passive coping response to behavioral challenge. Nevertheless, the effect of ATP infusion in the medial prefrontal cortex (mPFC) on the passive coping response was blocked by P2X2 but not P2X3 receptor deletion. Additionally, no deficits in a wide variety of behavioral tests were observed in P2X3 knockout mice. These findings demonstrate a role of P2X2 receptor in the mPFC in adenosine‐5′‐triphosphate modulation of the passive coping response to behavioral challenge and show that the P2X2/P2X3 receptor is dispensable for behaviors.