Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations.
Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations.
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发表时间：
1992
期刊：
影响因子：
3.3
通讯作者：
S. Ballinger;T. Schurr;A. Torroni;Y. Gan;J. A. Hodge;K. Hassan;K. H. Chen;Douglas C. Wallace
中科院分区：
文献类型：
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作者：
S. Ballinger;T. Schurr;A. Torroni;Y. Gan;J. A. Hodge;K. Hassan;K. H. Chen;Douglas C. Wallace
使用聚合酶链式反应 (PCR)、限制性内切酶分析和寡核苷酸杂交对来自 7 个亚洲人群的 153 个独立样本的人类线粒体 DNA (mtDNA) 进行序列变异调查。所有亚洲人群均在 nps 10394 和 10397 处共享两个古老的 AluI/DdeI 多态性，并且遗传相似，表明他们拥有共同的祖先。在越南人中观察到最大的 mtDNA 多样性和具有 HpaI/HincII 形态 1 的 mtDNA 的最高频率，表明亚洲人起源于南蒙古人种。在马来西亚发现了巴布亚新几内亚 (PNG) 创始种群的残余，并在亚洲沿海观察到了 COII/tRNA(Lys) 基因间缺失的显着频率曲线。系统发育分析表明COII/tRNA(Lys)区域的插入和缺失突变都发生了不止一次。
Human mitochondrial DNAs (mtDNAs) from 153 independent samples encompassing seven Asian populations were surveyed for sequence variation using the polymerase chain reaction (PCR), restriction endonuclease analysis and oligonucleotide hybridization. All Asian populations were found to share two ancient AluI/DdeI polymorphisms at nps 10394 and 10397 and to be genetically similar indicating that they share a common ancestry. The greatest mtDNA diversity and the highest frequency of mtDNAs with HpaI/HincII morph 1 were observed in the Vietnamese suggesting a Southern Mongoloid origin of Asians. Remnants of the founding populations of Papua New Guinea (PNG) were found in Malaysia, and a marked frequency cline for the COII/tRNA(Lys) intergenic deletion was observed along coastal Asia. Phylogenetic analysis indicates that both insertion and deletion mutations in the COII/tRNA(Lys) region have occurred more than once.