Undulation Instability of Epithelial Tissues
Undulation Instability of Epithelial Tissues
复制标题
DOI：
10.1103/physrevlett.106.158101
复制
发表时间：
2011-04-11
影响因子：
8.6
通讯作者：
Risler, Thomas
中科院分区：
文献类型：
--
作者：
Basan, Markus;Joanny, Jean-Francois;Risler, Thomas
将上皮细胞视为粘弹性基质附近的不可压缩流体，我们发现了一种新的流体动力学不稳定性，导致上皮细胞向基质中形成突起。这种不稳定性是在体内观察到的上皮指指的候选因素。它发生于足够大的黏度、细胞分裂率和上皮分裂区厚度。我们的工作为上皮和间质之间的界面波动和组织发育不良导致癌症侵袭的潜在机制提供了物理见解。
Treating the epithelium as an incompressible fluid adjacent to a viscoelastic stroma, we find a novel hydrodynamic instability that leads to the formation of protrusions of the epithelium into the stroma. This instability is a candidate for epithelial fingering observed in vivo. It occurs for sufficiently large viscosity, cell-division rate and thickness of the dividing region in the epithelium. Our work provides physical insight into a potential mechanism by which interfaces between epithelia and stromas undulate and potentially by which tissue dysplasia leads to cancerous invasion.