The Role of FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling.
The Role of FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling.
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FGF19和MALRD1在肠肝型胆汁酸信号转导中的作用
DOI：
10.3389/fendo.2021.799648
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发表时间：
2021
影响因子：
5.2
通讯作者：
Kohli R
中科院分区：
文献类型：
--
作者：
Wang LX;Frey MR;Kohli R
Bile acids are the catabolic end products of cholesterol metabolism that are best known for their role in the digestion of lipids. In the last two decades, extensive investigation has shown bile acids to be important signaling molecules in metabolic processes throughout the body. Bile acids are ligands that can bind to several receptors, including the nuclear receptor farnesoid X receptor (FXR) in ileal enterocytes. FXR activation induces the expression of fibroblast growth factor (FGF) 15/19, a hormone that can modulate bile acid levels, repress gluconeogenesis and lipogenesis, and promote glycogen synthesis. Recent studies have described a novel intestinal protein, MAM and LDL Receptor Class A Domain containing 1 (MALRD1) that positively affects FGF15/19 levels. This signaling pathway presents an exciting target for treating metabolic disease and bile acid-related disorders.
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DOI：
10.1038/nrm3528
发表时间：
2013-03
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
--
作者：
Dawson, Paul A
通讯作者：
Dawson, Paul A
影响因子：
16.2
作者：
Gerhard GS;Styer AM;Wood GC;Roesch SL;Petrick AT;Gabrielsen J;Strodel WE;Still CD;Argyropoulos G
通讯作者：
Argyropoulos G
影响因子：
4.9
作者：
Gallego-Escuredo, J. M.;Gomez-Ambrosi, J.;Villarroya, F.
通讯作者：
Villarroya, F.
影响因子：
29.4
作者：
Alemi F;Poole DP;Chiu J;Schoonjans K;Cattaruzza F;Grider JR;Bunnett NW;Corvera CU
通讯作者：
Corvera CU