Comparison of deltamethrin tablet formulation with liquid deltamethrin and permethrin for bednet treatment in The Gambia
Comparison of deltamethrin tablet formulation with liquid deltamethrin and permethrin for bednet treatment in The Gambia
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DOI：
10.1046/j.1365-3156.2001.00706.x
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发表时间：
2001-04-01
影响因子：
3.3
通讯作者：
Rowley, J
中科院分区：
文献类型：
--
作者：
Jawara, M;Pinder, M;Rowley, J
研究目的是比较三种制剂（溴氰菊酯片剂、溴氰菊酯液体和二氯苯醚菊酯液体）对病媒行为和持久性的影响。产品的接受程度，感知的副作用和用户的有效性的看法也进行了调查。在1998年雨季开始时，冈比亚一个村庄的255顶蚊帐被浸在三种杀虫剂中的一种。浸渍后立即进行的化学残留分析表明，液体杀虫剂达到了目标剂量，但片剂溴氰菊酯沉积量显著减少，但片剂制剂在5个月内的残留持续性最高。药敏试验表明，该地区按蚊对两种杀虫剂均敏感。所有三种制剂似乎都有效，因为在经处理的蚊帐下捕获的活按蚊或其他蚊子很少。这一结论得到了生物测定数据的支持，两种溴氰菊酯制剂在浸渍后不久和3个月时的死亡率均超过90%，溴氰菊酯液体和片剂在5个月时的死亡率分别为70.8%和79.6%。氯菊酯在所有时间的有效性均较低（72.4、86.8、59.0%）。村民们报告说，蘸药后没有严重的副作用。大多数（92%）使用者认为所有三种治疗方法都有效，大多数（93%）希望再次使用杀虫剂。因此，在冈比亚，溴氰菊酯片剂似乎与氯菊酯一样适用于处理蚊帐。此外，片剂制剂相当容易包装和分发。
The study aim was to compare three formulations, tablet deltamethrin, liquid deltamethrin and liquid permethrin, for their impact on vector behaviour and persistence. Product acceptance, perceived side-effects and user's perceptions of effectiveness were also investigated. At the beginning of the 1998 rainy season, 255 nets in a Gambian village were dipped in one of the three insecticides. Chemical residue analysis immediately after dipping showed that the target doses were reached for the liquid insecticides, but tablet deltamethrin deposited significantly less. Insecticide persistence at 5 months, however, was highest for the tablet formulation. Susceptibility tests established that Anophelines in this area were sensitive to both insecticides. All three formulations appeared effective as very few live Anophelines, or other mosquitoes, were caught under the treated nets. This conclusion was supported by the bioassay data with both deltamethrin formulations giving over 90% mortality soon after dipping and at 3 months, and at 5 months 70.8 and 79.6% were obtained for deltametrin liquid and tablet, respectively. Permethrin appeared less effective at all times (72.4, 86.8, 59.0%). There were no serious side-effects reported by the villagers following dipping. All three treatments were perceived as effective by the majority (92%) of users and most (93%) wanted to use the insecticide again. Deltamethrin tablets thus appear as good as permethrin for treating bednets in The Gambia. In addition, a tablet formulation is considerable easier to pack and distribute.