Modulation of use-dependent plasticity by D-amphetamine
Modulation of use-dependent plasticity by D-amphetamine
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DOI：
10.1002/ana.10056
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发表时间：
2002-01-01
影响因子：
11.2
通讯作者：
Cohen, LG
中科院分区：
文献类型：
--
作者：
Bütefisch, CM;Davis, BC;Cohen, LG
运动训练可诱发脑可塑性，这种可塑性被认为有助于脑损伤后的功能恢复。本研究的目的是确定是否管理的d-安非他明促进运动训练的使用依赖性可塑性的影响。健康志愿者在随机双盲、平衡设计中，在安慰剂或d-苯丙胺的作用下，在不同的时间段进行自愿拇指运动的训练。先前在药物未使用条件下的工作表明，这种训练会导致经颅磁刺激诱发的拇指运动方向和经颅磁刺激诱发的肌电图反应发生变化。该研究的终点指标是d-苯丙胺和安慰剂条件下经颅磁刺激诱发的运动学和肌电图反应的训练诱导变化的幅度。与安慰剂组相比，运动训练导致d-苯丙胺下使用依赖性可塑性的幅度增加、发展更快和持续时间更长。这些结果证明了d-苯丙胺对使用依赖性可塑性的促进作用，这是一种可能的机制，介导了这种药物对皮质损伤后功能恢复的有益作用。
Use-dependent plasticity, thought to contribute to functional recovery after bra-in injury, is elicited by motor training. The purpose of this study was to determine if administration of d-amphetamine facilitates the effects of motor training on use-dependent plasticity. Healthy human volunteers underwent a training period of voluntary thumb movements under the effects of placebo or d-amphetamine in different sessions in a randomized double-blind, counterbalanced design. Previous work in a drug-naive condition showed that such training causes changes in the direction of thumb movements evoked by transcranial magnetic stimulation and in transcranial magnetic stimulation-evoked electromyographic responses. The endpoint measure of the study was the magnitude of training-induced changes in transcranial magnetic stimulation-evoked kinematic and electromyographic responses in the d-amphetamine and in the placebo conditions. Motor training resulted in increased magnitude, faster development and longer lasting duration of use-dependent plasticity under d-amphetamine compared to the placebo session. These results document a facilitatory effect of d-amphetamine on use-dependent plasticity, a possible mechanism mediating the beneficial effect of this drug on functional recovery after cortical lesions.