Prevalence of elevated glycated hemoglobin in women with polycystic ovary syndrome
Prevalence of elevated glycated hemoglobin in women with polycystic ovary syndrome
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DOI：
10.1093/humrep/des039
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发表时间：
2012-05-01
影响因子：
6.1
通讯作者：
Moon, Shin Yong
中科院分区：
文献类型：
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作者：
Kim, Jin Ju;Choi, Young Min;Moon, Shin Yong
最近，美国糖尿病协会（ADA）包括糖化血红蛋白A1（C）（A1C）水平，作为Odiabetes诊断标准的组成部分，或者是糖尿病风险的诊断标准。进行了这项研究是为了检查多囊卵巢综合征（PCOS）的女性的渗出A1C'（Epsilon 5.7）的患病率和危险因素。匹配控件（匹配比为13）。所有受试者均由BMI（非肥胖25 kg/m（2）和肥胖的Epsilon 25 kg/m（2））进行分类，并且还根据BMI。的三分之一（31.2）分析了A1C的升高率。 PCOS患者的A1C升高。 PCOS和肥胖对照的肥胖女性（分别为23.5和20.0，p 1.0），A1C升高（Epsilon 5.7）的患病率相似，但是患有PCOS的非肥胖妇女（平均年龄为29.8 5.3岁）的A1C患病率较高。比非肥胖对照（分别为31.2对6.6，p 0.001）。对所有受试者的逻辑回归分析表明，如果女性患有PCOS，则A1C升高的几率是6.7倍（调整后的比值比6.67，95置信区间3.5012.70）。非肥胖患者的A1C高升高率高。 PCOS和与PCOS相关的A1C升高风险的增加表明PCOS本身可能与异常A1C状态有关。评估PCOS的年轻，非肥胖患者的A1C水平可能是筛查糖尿病的一种有用的新方法。
Recently, the American Diabetes Association (ADA) has included glycated hemoglobin A1(c) (A1C) level as a component of diagnostic criteria of odiabetes' or oincreased risk for diabetes'. This study was conducted to examine the prevalence of and risk factors for oelevated A1C' (epsilon 5.7) in women with polycystic ovary syndrome (PCOS).A1C was measured using an immunoturbidimetric assay, and was evaluated in 154 patients with PCOS and 469 age-matched controls (match ratio of 13). All subjects were categorized by BMI (non-obese 25 kg/m(2) and obese epsilon 25 kg/m(2)), and the prevalence of elevated A1C was also analyzed according to BMI.One-third (31.2) of the patients with PCOS had elevated A1C. The prevalence of elevated A1C (epsilon 5.7) was similar in obese women with PCOS and obese controls (23.5 and 20.0, respectively, P 1.0) but non-obese women with PCOS (mean age 29.8 5.3 years) had a higher prevalence of elevated A1C than non-obese controls (31.2 versus 6.6, respectively, P 0.001). Logistic regression analysis of all subjects showed that the odds that a woman has elevated A1C was 6.7 times higher if she has PCOS (adjusted odds ratio 6.67, 95 confidence interval 3.5012.70).The high prevalence of elevated A1C in non-obese patients with PCOS and an increased risk of elevated A1C associated with PCOS suggest that PCOS itself may be associated with abnormal A1C status. Assessing A1C level in young, non-obese patients with PCOS may be a useful new approach to screening for diabetes.