ADAPTATION TO SHORT-TERM RESPIRATORY EFFECTS OF OZONE IN MEN EXPOSED REPEATEDLY
ADAPTATION TO SHORT-TERM RESPIRATORY EFFECTS OF OZONE IN MEN EXPOSED REPEATEDLY
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DOI：
10.1152/jappl.1977.43.1.82
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发表时间：
1977-01-01
影响因子：
3.3
通讯作者：
COLLIER, CR
中科院分区：
文献类型：
--
作者：
HACKNEY, JD;LINN, WS;COLLIER, CR
为了探讨是否适应，修改一些急性影响的臭氧（O3）暴露可以在人类中发展，6名男性志愿者呼吸高反应性暴露在受控环境室中0.5 ppm的O3 2小时/天，连续4天的条件下模拟环境污染暴露。1例受试者几乎没有可测量的反应，而5例受试者在暴露第1-3天显示功能减退，在第4天基本上逆转。症状反应通常是生理反应的一部分。至少有一些人适应了在严重的社区空气污染事件中出现的浓度的O3暴露，在一定程度上，明显的急性呼吸影响被预防。O3的其他不利影响可能无法通过这种适应来防止。
To investigate whether adaptation which modifies some acute effects of ozone (O3) exposure can develop in humans, 6 male volunteers with respiratory hyperreactivity were exposed in a controlled environment chamber to 0.5 ppm O3 2 h/day for 4 successive days under conditions simulating ambient pollution exposures. One subject showed little measurable response, while 5 showed function decrement on exposure days 1-3 which was largely reversed by day 4. Symptom responses generally paralleled the physiological responses. At least some humans adapt to O3 exposure at concentrations occurring in severe community air pollution episodes, to the extent that obvious acute respiratory effects are prevented. Other adverse effects of O3 may not be prevented by this adaptation.