Antiviral treatment for patients hospitalized with 2009 pandemic influenza A (H1N1).
Antiviral treatment for patients hospitalized with 2009 pandemic influenza A (H1N1).
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DOI：
10.1056/nejmopv0910738
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发表时间：
2009-12-03
期刊：
影响因子：
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通讯作者：
Uyeki, Tim
中科院分区：
文献类型：
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作者：
Uyeki, Tim
随着2009年H1N1大流行的进行，许多临床医生正在为流感患者提供护理。以前，虽然抗病毒治疗被推荐，但临床医生可能并不总是给季节性流感住院患者开抗病毒治疗，这可能是因为认为抗病毒治疗的益处有限。在无并发症的季节性流感门诊患者中进行的对照试验报告，与安慰剂相比，在发病48小时内开始抗病毒治疗时，疾病持续时间缩短约1天，严重程度降低。然而，来自观察性研究的证据支持神经氨酸酶抑制剂（奥司他韦或...
With the 2009 H1N1 pandemic well under way, many clinicians are providing care to patients with influenza. Previously, although antiviral treatment was recommended,1,2clinicians may not always have prescribed it to patients hospitalized with seasonal influenza, perhaps because of a perception that antiviral treatment had limited benefit. Controlled trials conducted among outpatients with uncomplicated seasonal influenza reported a reduction of approximately 1 day in the duration of illness and reduced severity when antiviral treatment was initiated within 48 hours of illness onset, as compared with placebo. However, evidence from observational studies supports the benefit of neuraminidase inhibitors (oseltamivir or . . .