Epicardial Adipose Tissue Radiodensity Is Independently Related to Coronary Atherosclerosis A Multidetector Computed Tomography Study
Epicardial Adipose Tissue Radiodensity Is Independently Related to Coronary Atherosclerosis A Multidetector Computed Tomography Study
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DOI：
10.1253/circj.cj-10-0441
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发表时间：
2011-02-01
影响因子：
3.3
通讯作者：
Ruzyllo, Witold
中科院分区：
文献类型：
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作者：
Pracon, Radoslaw;Kruk, Mariusz;Ruzyllo, Witold
背景：初步研究表明，心外膜脂肪组织（EAT）可能同时具有抗和促动脉粥样硬化的特性。由于通过多探测器计算机断层扫描（MDCT）评估的选定人体组织的不同放射密度已被证明反映了生物学特性的差异，因此本研究调查了EAT的促动脉粥样硬化特性可能与其放射密度有关的假设。方法和结果：本研究纳入164例疑似冠状动脉疾病（CAD）患者（女性82例，平均年龄58.8±11.1岁），行MDCT冠状动脉造影。冠状动脉粥样硬化定义为：(1)冠心病（即存在至少1个冠状动脉狭窄>= 50%）和(2)冠状动脉钙（CAC）由Agatston评分测定。通过MDCT评估EAT放射密度，平均为-81.00 +/- 4.64 HO （Hounsfield单位（HO）标度）。平均CAC评分为96.0±220.0。冠心病患者（n=36）的EAT放射密度高于非冠心病患者(-78.99 +/- 4.12 vs -81.57 +/- 4.64 HO， P
Background: Preliminary research indicates that epicardial adipose tissue (EAT) may display both anti-and pro-atherosclerotic properties. Because the varying radiodensities of selected human tissues assessed by multidetector computed tomography (MDCT) has been shown to reflect differences in biological characteristics, the present study investigated the hypothesis that the proatherosclerotic properties of EAT may be linked to its radiodensity.Methods and Results: The study included 164 consecutive patients (82 females, mean age 58.8 +/- 11.1 years) with suspected coronary artery disease (CAD) undergoing MDCT coronary angiography. Coronary atherosclerosis was defined as: (1) CAD (ie, presence of at least 1 coronary stenosis >= 50%) and (2) coronary artery calcium (CAC) determined by Agatston score. EAT radiodensity was assessed by MDCT and averaged -81.00 +/- 4.64 HO (Hounsfield unit (HO) scale). Mean CAC score was 96.0 +/- 220.0. Patients with CAD (n=36) showed higher EAT radiodensity than patients without CAD (-78.99 +/- 4.12 vs. -81.57 +/- 4.64 HO, P