The-308 G/A polymorphism of tumor necrosis factor alpha gene is not associated with migraine
The-308 G/A polymorphism of tumor necrosis factor alpha gene is not associated with migraine
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DOI：
10.1163/156856905774482814
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发表时间：
2005-01-01
期刊：
影响因子：
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通讯作者：
Bayazit, Yildirim A.
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文献类型：
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作者：
Herken, Hasan;Erdal, M. Emin;Bayazit, Yildirim A.
背景与目的：探讨TNF-α基因308 G/A多态性与偏头痛的相关性。方法：采用聚合酶链反应-限制性片段长度多态性检测方法，检测60例偏头痛患者和62例健康对照者的TNF-308 G/A多态性。结果：TNF-α-308 G/A多态性与性别、癫痫家族史、癫痫家族史无显着相关性。偏头痛和先兆。在对照组中，G和A等位基因的频率分别为0.93和0.07。偏头痛患者的相应值为 0.94 和 0.06。偏头痛患者和对照组的等位基因频率和基因型之间没有显着差异(p=0.85)。结论：TNF-α-308 G/A多态性与偏头痛和先兆无关。
Background and objective: To investigate the association between 308 G/A polymorphism of TNF-alpha gene and migraine.Methods: Polymerase chain reaction-restriction fragment length polymorphism assay was used to determine TNF-308 G/A polymorphism in 60 migraineurs and 62 healthy controls.Results: There was no significant relationship between TNF-alpha-308 G/A polymorphism and gender, family history of epilepsy, family history of migraine and aura. In the control group, the frequencies of G and A alleles were 0.93 and 0.07, respectively. The corresponding values were 0.94 and 0.06 in the migraineurs. There was no significant difference between the allele frequencies and genotypes of the migraineurs and controls (p=0.85).Conclusion: TNF-alpha-308 G/A polymorphism is not associated with migraine and aura.