Increased expression of transforming growth factor-beta in renal disease.
Increased expression of transforming growth factor-beta in renal disease.
复制标题
肾脏疾病中转化生长因子-β 的表达增加。
DOI：
10.1097/00041552-199407000-00011
复制
发表时间：
1994
影响因子：
3.2
通讯作者：
Border,WA
中科院分区：
文献类型：
--
作者：
Ketteler,M;Noble,NA;Border,WA
Transforming growth factor-[beta](TGF-[beta]) is a multi functional cytokine and a major regulator of tissue repair and extracellular matrix. Recent studies show that TGF-[beta] over expression in experimental and human kidney diseases leads to progressive glomerular and tubulointerstitial scarring and renal failure. New evidence suggests that angiotensin-converting enzyme inhibitors and a low-protein diet may slow the progression of chronic kidney diseases in part by suppressing TGF-[beta] over expression. New therapies may prevent progressive fibrosis in chronic kidney disease by suppressing the action of TGF-[beta]
