Lymph node involvement in immunohistochemistry-based molecular classifications of breast cancer.
Lymph node involvement in immunohistochemistry-based molecular classifications of breast cancer.
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DOI：
10.1016/j.jss.2013.06.048
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发表时间：
2013-12
影响因子：
2.2
通讯作者：
Chao, Celia
中科院分区：
文献类型：
--
作者：
Howland, Nicholas K.;Driver, Teryn D.;Sedrak, Michael P.;Wen, Xianfeng;Dong, Wenli;Hatch, Sandra;Eltorky, Mahmoud A.;Chao, Celia
乳腺癌的每种分子亚型的预后和治疗方案不同，但每种亚型的区域淋巴结（LN）转移的风险尚未得到充分研究。由于LN状态是最重要的预后预测因子，本研究的目的是研究五种乳腺癌分子亚型中每一种的LN转移倾向。根据IRB批准的方案，我们回顾性审查了2004年1月至2012年6月所有病理证实的乳腺癌病例的图表。将5种亚型定义为管腔A型（激素受体+，Ki 67低）、管腔B型（激素受体+，Ki 67高）、管腔-人表皮生长因子受体2（HER-2）、HER-2富集型（激素受体阴性）和三阴性（TN）。共有375例具有完整数据的患者按亚型分类：95例（25.3%）管腔A型，120例（32%）管腔B型，69例（18.4%）管腔HER-2型，26例（6.9%）HER-2富集型和65例（17.3%）TN型。在单因素分析中，年龄（<50岁）、较高的肿瘤分级、HER-2 +状态、肿瘤大小和分子亚型是LN阳性的显著因素。分子亚型与肿瘤大小密切相关（X2; p=0.0004）;因此，多变量logistic回归未将分子亚型确定为预测LN阳性的自变量。管腔A型肿瘤LN转移的风险最低，而管腔HER-2亚型LN转移的风险最高。免疫组织化学为基础的分子分类可以很容易地进行和知识的影响LN状态的因素可能有助于治疗决策。
Prognosis and treatment options differ for each molecular subtype of breast cancer, but risk of regional lymph node (LN) metastasis for each subtype has not been well-studied. Since LN status is the most important predictor for prognosis, the aim of this study is to investigate the propensity for LN metastasis in each of the five breast cancer molecular subtypes. Under an IRB-approved protocol, we retrospectively reviewed the charts of all pathologically confirmed breast cancer cases from 1/2004 to 6/2012. Five subtypes were defined as luminal A (hormone receptor +, Ki67 low), luminal B (hormone receptor+, Ki67 high), luminal-human epidermal growth factor receptor 2 (HER-2), HER-2-enriched (hormone receptor negative), and triple negative (TN). A total of 375 patients with complete data were classified by subtype: 95 (25.3%) luminal A, 120 (32%) luminal B, 69 (18.4%) luminal-HER-2, 26 (6.9%) HER-2-enriched, and 65 (17.3%) TN. On univariate analysis, age (<50), higher tumor grade, HER-2 + status, tumor size, and molecular subtype were significant for LN positivity. Molecular subtype correlated strongly with tumors size (X2; p=0.0004); therefore, multivariable logistic regression did not identify molecular subtype as an independent variable to predict LN positivity. Luminal A tumors have the lowest risk of LN metastasis, while luminal HER-2 subtype has the highest risk of LN metastasis. Immunohistochemical-based molecular classification can be readily performed and knowledge of the factors that affect LN status may help with treatment decisions.
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影响因子：
2.5
作者：
Altomare, Vittorio;Guerriero, Gabriella;Rabitti, Carla
通讯作者：
Rabitti, Carla
影响因子：
9.6
作者：
Xing, Y.;Foy, M.;Cormier, J. N.
通讯作者：
Cormier, J. N.
DOI：
10.1186/bcr2124
发表时间：
2008
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Wirapati P;Sotiriou C;Kunkel S;Farmer P;Pradervand S;Haibe-Kains B;Desmedt C;Ignatiadis M;Sengstag T;Schütz F;Goldstein DR;Piccart M;Delorenzi M
通讯作者：
Delorenzi M
影响因子：
45.3
作者：
Voduc, K. David;Cheang, Maggie C. U.;Kennecke, Hagen
通讯作者：
Kennecke, Hagen
DOI：
10.1073/pnas.0932692100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Sorlie, T;Tibshirani, R;Botstein, D
通讯作者：
Botstein, D