PREDICTORS OF DISABILITY IN A LONGITUDINAL SAMPLE OF PATIENTS WITH RHEUMATOID-ARTHRITIS
PREDICTORS OF DISABILITY IN A LONGITUDINAL SAMPLE OF PATIENTS WITH RHEUMATOID-ARTHRITIS
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DOI：
10.1136/ard.51.5.581
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发表时间：
1992-05-01
影响因子：
27.4
通讯作者：
FRIES, JF
中科院分区：
文献类型：
--
作者：
LEIGH, JP;FRIES, JF
来自健康评估问卷(HAQ)的信息被用来确定在1981年测量的哪些变量成功地预测了1989年的疾病严重程度以及在美国加利福尼亚州圣克拉拉县330名居民中疾病严重程度的八年变化。这项研究是探索性的，没有提出任何先前的假设。使用单变量相关和逐步线性回归，一些变量的初始值被发现是有用的预测因子，依次包括：HAQ残疾指数、疼痛等级、全球健康状况、关节压痛、工作时间少、年龄、女性、从未结婚、寡居和作为操作工的职业(例如，干墙安装工、装配工)。数据表明，对于1981年患有严重疾病的人来说，八年内病情恶化的速度最慢。数学上的一致性表明，如果将1981年的伤残指数作为协变量输入，则对严重程度变化的分析与对1989年严重程度的分析是相同的。HAQ残疾指数的初始水平是到目前为止最强的预测变量，并为未来损害的可能性提供了一个临床上重要的衡量标准。
Information from the Health Assessment Questionnaire (HAQ) is used to identify which variables measured in 1981 successfully predict the severity of disease in 1989 and the eight year change in severity of disease in a sample of 330 residents of Santa Clara County, California, USA. This study is exploratory and no previous hypotheses are made. Using univariate correlations and stepwise linear regressions, initial values of a number of variables are found to be useful predictors including, in order: the HAQ disability index, pain scale, global health status, tender joints, few workhours, age, female sex, never married, widowhood, and occupation as operative (e.g. dry wall installers, assemblers). Data suggest that deterioration over eight years is least rapid for those with severe disease in 1981. A mathematical identity suggests that analyses of the changes in severity versus analyses of 1989 severity are identical, provided that the 1981 disability index is entered as a covariate. The initial level of the disability index of the HAQ is by far the strongest predictive variable and provides a clinically important gauge for the likelihood of future impairment.