Excitement about calcium signaling in inexcitable cells.
Excitement about calcium signaling in inexcitable cells.
复制标题
对不可兴奋细胞中钙信号传导的兴奋。
DOI：
10.1126/science.8235587
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发表时间：
1993
期刊：
影响因子：
56.9
通讯作者：
J. Putney
中科院分区：
文献类型：
--
作者：
J. Putney
Calcium ions act as intracellular messen-gers that control the functions of cells in many living systems. Traditionally, calcium signaling has been divided into separate categories: studies focusing on electrically excitable cells, such as nerve and muscle, and studies focusing on electrically in-excitable cells, such as epithelial or blood cells. Both excitable and inexcitable cells utilize calcium sequestered in cytoplasmic storage compartments for signaling, but ex-citable cells rely on a" calcium-induced cal-cium release"(CICR) mechanism (1-3) while, for inexcitable cells, the predomi-nant mechanism for release is triggered by a diffusible messenger, inositol 1, 4, 5-trisphosphate (1P3)(4). Although signaling in both types of cells is influenced by plasma membrane calcium channels, the channels in the plasma membrane of inexcitable cells apparently are not regulated by mem-brane potential andtheir pharmacology is different from that of the voltage-sensitive calcium channels of excitable cells. Recent discoveries, however, have revealed that calcium signaling mechanisms in excitable and inexcitable cells are more similar than previously suspected. In electrically inexcitable cells, calcium signaling typically is a biphasic process (5). Neurotransmitters and hormones stimulate an intracellular organelle to release stored calcium into the cytoplasm, and this release is followed by entry of calcium into the cy-toplasm from the extracellular space. The
影响因子：
56.9
作者：
FINCH, EA;TURNER, TJ;GOLDIN, SM
通讯作者：
GOLDIN, SM
影响因子：
56.9
作者：
BADING, H;GINTY, DD;GREENBERG, ME
通讯作者：
GREENBERG, ME
影响因子：
4
作者：
PUTNEY, JW
通讯作者：
PUTNEY, JW