Cyclopropanation of alkenes with CH2I2/Et3Al by the phase-vanishing method based on fluorous phase screen
Cyclopropanation of alkenes with CH2I2/Et3Al by the phase-vanishing method based on fluorous phase screen
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DOI：
10.1016/j.jfluchem.2008.06.004
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发表时间：
2008-10-01
影响因子：
1.9
通讯作者：
Ryu, Ilhyong
中科院分区：
文献类型：
--
作者：
Matsubara, Hiroshi;Tsukida, Masaaki;Ryu, Ilhyong
采用全氟己烷作为屏蔽相的消失相法研究了CH_2I_2/Et_2Zn和CH_2I_2/Et_3Al的环丙烷化反应。以Et_3Al为类卡宾发生剂，反应顺利进行，高产率地得到了所需的环丙烷衍生物。PV环丙烷化需要2或3天才能完成，然而，在底部CH 2 I2层消失后通过剧烈搅拌也实现了反应时间减少2-3倍。(C)2008 Elsevier B. V.保留所有权利。
Phase-vanishing (PV) method using perfluorohexanes as a screen phase was applied to cyclopropa nation reactions with CH2I2/Et2Zn and CH2I2/Et3Al. When Et3Al was used as a carbenoid generator, the reaction proceeded smoothly and desired cyclopropane derivatives were obtained in high yield. The PV cyclopropa nation took 2 or 3 days to complete, however, reduction of reaction time by a factor of 2-3 was also achieved by vigorous stirring after the bottom CH2I2 layer disappeared. (C) 2008 Elsevier B.V. All rights reserved.