Choline metabolism in malignant transformation.
Choline metabolism in malignant transformation.
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DOI：
10.1038/nrc3162
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发表时间：
2011-11-17
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胆碱代谢异常正在成为与肿瘤发生和肿瘤进展相关的代谢标志。转化后，控制合成代谢和分解代谢途径的酶的调节导致含胆碱前体和膜磷脂分解产物的水平增加。这些增加的水平与增殖有关，最近的研究强调致癌信号和胆碱代谢之间复杂的相互作用。由于含胆碱化合物可通过非侵入性磁共振波谱（MRS）检测，因此这些化合物水平的增加提供了转化、分期和对治疗反应的非侵入性生物标志物。此外，胆碱代谢的酶，如胆碱激酶，为图像引导的癌症治疗提供了新的靶点。
Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, the modulation of enzymes that control anabolic and catabolic pathways causes increased levels of choline-containing precursors and breakdown products of membrane phospholipids. These increased levels are associated with proliferation, and recent studies emphasize the complex reciprocal interactions between oncogenic signalling and choline metabolism. Because choline-containing compounds are detected by non-invasive magnetic resonance spectroscopy (MRS), increased levels of these compounds provide a non-invasive biomarker of transformation, staging and response to therapy. Furthermore, enzymes of choline metabolism, such as choline kinase, present novel targets for image-guided cancer therapy.