Ultrashort time-to-echo MR morphology of cartilaginous endplate correlates with disc degeneration in the lumbar spine.
Ultrashort time-to-echo MR morphology of cartilaginous endplate correlates with disc degeneration in the lumbar spine.
复制标题
软骨终板的超短回波时间 MR 形态与腰椎椎间盘退变相关。
DOI：
10.1007/s00586-023-07739-9
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Bae,WonC
中科院分区：
文献类型：
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作者：
Finkenstaedt,Tim;Siriwananrangsun,Palanan;Masuda,Koichi;Bydder,GraemeM;Chen,KarenC;Bae,WonC
目的应用MRI超短回波时间（ultrashortechottime，UTE）序列，研究人腰椎软骨终板（cartilaginousendplate，CEP）异常的发生率及其与椎间盘退变的关系。在UTE图像上，CEP形态被定义为具有线性高信号强度的“正常”或具有局灶性信号丢失和/或不规则的“异常”。在自旋回波图像上，确定椎间盘分级和髓核（NP）和纤维环（AF）的T2值。分析了547个CEP和284个光盘。确定了年龄、性别和水平对CEP形态、椎间盘分级和T2值的影响。CEP异常对椎间盘分级，T2的NP，T2的AF的影响也determined. ResultsCEP异常的总体患病率为33%，它往往增加与年龄较大（p = 0.08），并在较低的脊柱水平L5比L2或L3（p = 0.001）。在较老的脊柱（p < 0.001）和L4-5较低的椎间盘水平（p < 0.05），椎间盘分级较高，NP的T2值较低。CEP与椎间盘退变之间存在显著相关性，CEP异常的椎间盘分级高（p < 0.01），NP的T2值低（p < 0.05）。结论CEP异常与椎间盘退变密切相关，提示椎间盘退变的病因。
PurposeUsing ultrashort echo time (UTE) MRI, we determined prevalence of abnormal cartilaginous endplate (CEP), and the relationship between CEP and disc degeneration in human lumbar spines.Materials and methodsLumbar spines from 71 cadavers (age 14–74 years) were imaged at 3 T using sagittal UTE and spin echo T2 map sequences. On UTE images, CEP morphology was defined as “normal” with linear high signal intensity or “abnormal” with focal signal loss and/or irregularity. On spin echo images, disc grade and T2 values of the nucleus pulposus (NP) and annulus fibrosus (AF) were determined. 547 CEPs and 284 discs were analysed. Effects of age, sex, and level on CEP morphology, disc grade, and T2 values were determined. Effects of CEP abnormality on disc grade, T2 of NP, and T2 of AF were also determined.ResultsOverall prevalence of CEP abnormality was 33% and it tended to increase with older ages (p = 0.08) and at lower spinal levels of L5 than L2 or L3 (p = 0.001). Disc grades were higher and T2 values of the NP were lower in older spines (p < 0.001) and at lower disc level of L4-5 (p < 0.05). We found significant association between CEP and disc degeneration; discs adjacent to abnormal CEPs had high grades (p < 0.01) and lower T2 values of the NP (p < 0.05).ConclusionThese results suggest that abnormal CEPs are frequently found, and it associates significantly with disc degeneration, suggesting an insight into pathoetiology of disc degeneration.