The twists and turns of β-peptides
The twists and turns of β-peptides
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DOI：
10.1034/j.1399-3011.1999.00131.x
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发表时间：
1999-09-01
期刊：
影响因子：
--
通讯作者：
Hamuro, Y
中科院分区：
文献类型：
--
作者：
DeGrado, WF;Schneider, JP;Hamuro, Y
最近，人们发现由-氨基酸组成的肽能够采用新的二级结构，这表明由-氨基酸组成的肽并不是唯一能够折叠成明确结构的肽。由-氨基酸残基组成的环肽和无环肽采用旋转、螺旋和片状构象。在这里，我们讨论了单个取代β -氨基酸的合成和构象偏好，以及由这些残基组成的肽可能采用的结构。
Recently, it has been discovered that peptides composed of beta-amino acids are capable of adopting novel secondary structures demonstrating that peptides composed of alpha-amino acids are not unique in their ability to fold into well-defined structures. Cyclic as well as acyclic peptides composed of beta-amino acid residues adopt turn, helical, and sheet-like conformations. Here, we discuss the synthesis and conformational preferences of individual, substituted beta-amino acids as well as the structures that peptides composed of these residues, beta-peptides, may adopt.