Impact of aging on antigen presentation cell function of dendritic cells.
Impact of aging on antigen presentation cell function of dendritic cells.
复制标题
DOI：
10.1016/j.coi.2013.05.016
复制
发表时间：
2013-08
影响因子：
7
通讯作者：
Goldstein DR
中科院分区：
文献类型：
--
作者：
Wong C;Goldstein DR
Older people exhibit increased mortality to infections and cancer as compared to younger people, indicating that aging impairs immunity. Dendritic cells (DCs) are key for bridging the innate and adaptive arms of the immune system by priming antigen specific T cells. Discerning how aging impacts DC function to initiate adaptive immune responses is of great biomedical importance as this could lead to the development of novel therapeutics to enhance immunity with aging. This review details reports indicating that aging impairs the antigen presenting function of DCs but highlights other studies indicating preserved DC function with aging. How aging impacts antigen presentation by DCs is complex and without a clear unifying biological underpinning.
登录
查看更多内容
DOI：
10.1084/jem.20060401
发表时间：
2006-08-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Guiducci C;Ott G;Chan JH;Damon E;Calacsan C;Matray T;Lee KD;Coffman RL;Barrat FJ
通讯作者：
Barrat FJ
影响因子：
5.3
作者：
Jiang, Jiu;Fisher, Erin;Bennett, Andrew J.;Murasko, Donna M.
通讯作者：
Murasko, Donna M.
DOI：
10.3402/pba.v2i0.18052
发表时间：
2012
期刊：
Pathobiology of aging & age related diseases
影响因子：
--
作者：
Asquith M;Haberthur K;Brown M;Engelmann F;Murphy A;Al-Mahdi Z;Messaoudi I
通讯作者：
Messaoudi I
DOI：
10.4049/jimmunol.0901296
发表时间：
2010-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jones SC;Brahmakshatriya V;Huston G;Dibble J;Swain SL
通讯作者：
Swain SL
影响因子：
4.5
作者：
Paula, Carine;Motta, Adriana;Bonorino, Cristina
通讯作者：
Bonorino, Cristina