Amygdala response to negative images in postpartum vs nulliparous women and intranasal oxytocin.
Amygdala response to negative images in postpartum vs nulliparous women and intranasal oxytocin.
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DOI：
10.1093/scan/nss100
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发表时间：
2014
影响因子：
4.2
通讯作者：
Heather A. Rupp;T. James;E. Ketterson;D. Sengelaub;B. Ditzen;J. Heiman
中科院分区：
文献类型：
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作者：
Heather A. Rupp;T. James;E. Ketterson;D. Sengelaub;B. Ditzen;J. Heiman
新妈妈的神经内分泌状态可能通过催产素对边缘系统的调节作用而改变其对环境中应激源的神经处理。我们预测，与未产妇女相比，产后杏仁核对负面刺激的敏感性将被抑制，这种抑制将通过给予催产素鼻喷雾剂来调节。我们测量了29名产后妇女和30名未生育妇女在扫描前接受催产素鼻喷雾剂或安慰剂的大脑激活（fMRI）和主观唤醒对消极唤醒图片的反应。暴露前后尿皮质醇水平也被测量。产后妇女（安慰剂）表现出较低的右杏仁核激活对负面图像的反应，较低的皮质醇和较低的负面照片唤醒评级对未生育妇女。与安慰剂相比，接受催产素治疗的未生育妇女右侧杏仁核的激活程度较低。安慰剂组的皮质醇水平，以及所有女性的觉醒等级，都与右侧杏仁核的激活呈正相关。总之，这些发现表明，未经治疗的产后妇女与未分娩妇女相比，杏仁核激活和主观负性唤醒都有所减少，支持了产后妇女对唤醒刺激的神经反应减弱的假设。催产素的因果作用和潜在影响的时间需要进一步的研究。
The neuroendocrine state of new mothers may alter their neural processing of stressors in the environment through modulatory actions of oxytocin on the limbic system. We predicted that amygdala sensitivity to negatively arousing stimuli would be suppressed in postpartum compared to nulliparous women and that this suppression would be modulated by administration of oxytocin nasal spray. We measured brain activation (fMRI) and subjective arousal in response to negatively arousing pictures in 29 postpartum and 30 nulliparous women who received either oxytocin nasal spray or placebo before scanning. Pre- and post-exposure urinary cortisol levels were also measured. Postpartum women (placebo) demonstrated lower right amygdala activation in response to negative images, lower cortisol and lower negative photo arousal ratings to nulliparous women. Nulliparous women receiving oxytocin had lower right amygdala activation compared to placebo. Cortisol levels in the placebo group, and ratings of arousal across all women, were positively associated with right amygdala activation. Together, these findings demonstrate reductions in both amygdala activation and subjective negative arousal in untreated postpartum vs nulliparous women, supporting the hypothesis of an attenuated neural response to arousing stimuli in postpartum women. A causal role of oxytocin and the timing of potential effects require future investigation.