The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation.
The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation.
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DOI：
10.3390/ijms17010003
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发表时间：
2015-12-22
影响因子：
5.6
通讯作者：
Hoyne GF
中科院分区：
文献类型：
--
作者：
Yabas M;Elliott H;Hoyne GF
前mrna的选择性剪接有助于增强哺乳动物细胞内的遗传多样性，通过增加一个基因产物可以产生的蛋白质同种异构体的数量。这为宿主细胞改变蛋白质功能提供了很大的灵活性，但是当剪接发生失调时，这可能对健康和疾病产生重要影响。选择性剪接在哺乳动物免疫系统中广泛应用于控制抗原特异性淋巴细胞的发育和功能。在这篇综述中，我们将研究产生免疫系统中调节细胞凋亡、淋巴细胞分化、激活和稳态的关键蛋白的pre- mrna的剪接，并讨论剪接缺陷如何导致疾病。我们将描述反式作用因子的破坏，如异质核核糖核蛋白（hnRNPs），如何影响免疫系统中的细胞存活和分化。
Alternative splicing of pre-mRNA helps to enhance the genetic diversity within mammalian cells by increasing the number of protein isoforms that can be generated from one gene product. This provides a great deal of flexibility to the host cell to alter protein function, but when dysregulation in splicing occurs this can have important impact on health and disease. Alternative splicing is widely used in the mammalian immune system to control the development and function of antigen specific lymphocytes. In this review we will examine the splicing of pre-mRNAs yielding key proteins in the immune system that regulate apoptosis, lymphocyte differentiation, activation and homeostasis, and discuss how defects in splicing can contribute to diseases. We will describe how disruption to trans-acting factors, such as heterogeneous nuclear ribonucleoproteins (hnRNPs), can impact on cell survival and differentiation in the immune system.