Structural reorganization of phosphatidylcholine vesicle membranes by poly(2-ethylacrylic acid): influence of the molecular weight of the polymer
Structural reorganization of phosphatidylcholine vesicle membranes by poly(2-ethylacrylic acid): influence of the molecular weight of the polymer
复制标题
聚（2-乙基丙烯酸）对磷脂酰胆碱囊泡膜的结构重组：聚合物分子量的影响
DOI：
--
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
D. Tirrell
中科院分区：
文献类型：
--
作者：
U. Schroeder;D. Tirrell
Three samples of poly(2-ethylacrylic acid) (PEAA) of different molecular weights (M_w = 164000,
43000, and 12000) were prepared by radical polymerization of 2-ethylacrylic acid in bulk. The conformational
properties of the samples were determined and correlated with the pH-dependent structural reorganization
observed in phosphatidylcholine vesicles suspended in the respective polymer solutions. In all experiments
the sample of lowest molecular weight behaved differently from the other two: The cooperativity of the
conformational transition was reduced and the transition midpoint was shifted to lower pH as compared to
the samples of higher molecular weight. These effects of polymer molecular weight were reflected in the behavior
of the vesicle-to-micelle transition observed upon acidification of aqueous mixtures of PEAA and dipalmitoylphosphatidylcholine.
