Role of GABAergic mechanisms in the central regulation of arterial pressure.
Role of GABAergic mechanisms in the central regulation of arterial pressure.
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GABA能机制在动脉压的中枢调节中的作用。
DOI：
10.1093/eurheartj/8.suppl_b.133
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发表时间：
1987
影响因子：
39.3
通讯作者：
WilbeJr,JH
中科院分区：
文献类型：
--
作者：
DiMicco,JA;Abshire,VM;Shekhar,A;WilbeJr,JH
γ-氨基丁酸(GABA)可能是哺乳动物中枢神经系统中最常见的神经递质。因此，不足为奇的是，通过自主神经系统调节体动脉压的神经回路利用了许多在解剖和功能上截然不同的GABA能抑制机制。本文将首先总结我们实验室和其他研究人员的发现，这些发现表明其中一些在哺乳动物脑干中的作用，其次，追踪一系列研究，指出前脑中一种特殊的GABA能抑制机制，可能与实验性和人类高血压有关。
Gamma aminobutyric acid (GABA) may represent the single most prevalent neurotransmitter in the mammalian central nervous system. Consequently, it should come as little surprise that the neural circuitry concerned with regulating systemic arterial pressure through the autonomic nervous system utilizes a number of GABAergic inhibitory mechanisms which are anatomically and functionally distinct. This article will, first, summarize findings from our laboratory and others which suggest some of these roles in the mammalian brainstem, and, second, trace a line of research pointing to a particular GABAergic inhibitory mechanism in the forebrain that may have some relevance to experimental and human hypertension.